2. Membrane Transporter/Ion Channel
  3. SGLT
  4. Empagliflozin-d4

Empagliflozin-d4  (Synonyms: BI 10773-d4)

Cat. No.: HY-15409S Purity: 97.64%
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Empagliflozin-d4 is deuterium labeled Empagliflozin. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for human SGLT-2[1].

For research use only. We do not sell to patients.

Empagliflozin-d<sub>4</sub> Chemical Structure

Empagliflozin-d4 Chemical Structure

CAS No. : 2749293-95-4

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1 mg USD 350 In-stock
5 mg USD 950 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Empagliflozin-d4:

Empagliflozin-d4 Related Antibodies

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Description

Empagliflozin-d4 is deuterium labeled Empagliflozin. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for human SGLT-2[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Empagliflozin-d4 Related Antibodies
Molecular Weight

454.93

Formula

C23H23D4ClO7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC(C=CC([C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)=C2)=C2CC3=C(C([2H])=C(C([2H])=C3[2H])O[C@H]4CCOC4)[2H]
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (109.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1981 mL 10.9907 mL 21.9814 mL
5 mM 0.4396 mL 2.1981 mL 4.3963 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1981 mL 10.9907 mL 21.9814 mL 54.9535 mL
5 mM 0.4396 mL 2.1981 mL 4.3963 mL 10.9907 mL
10 mM 0.2198 mL 1.0991 mL 2.1981 mL 5.4954 mL
15 mM 0.1465 mL 0.7327 mL 1.4654 mL 3.6636 mL
20 mM 0.1099 mL 0.5495 mL 1.0991 mL 2.7477 mL
25 mM 0.0879 mL 0.4396 mL 0.8793 mL 2.1981 mL
30 mM 0.0733 mL 0.3664 mL 0.7327 mL 1.8318 mL
40 mM 0.0550 mL 0.2748 mL 0.5495 mL 1.3738 mL
50 mM 0.0440 mL 0.2198 mL 0.4396 mL 1.0991 mL
60 mM 0.0366 mL 0.1832 mL 0.3664 mL 0.9159 mL
80 mM 0.0275 mL 0.1374 mL 0.2748 mL 0.6869 mL
100 mM 0.0220 mL 0.1099 mL 0.2198 mL 0.5495 mL
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Empagliflozin-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Empagliflozin-d42749293-95-4BI 10773-d4SGLTSodium-dependent glucose cotransportersInhibitorinhibitorinhibit

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