2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Ethyl azetidine-3-carboxylate hydrochloride

Ethyl azetidine-3-carboxylate hydrochloride 

Cat. No.: HY-W052600 Purity: ≥98.0%
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Ethyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Ethyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2]

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Ethyl azetidine-3-carboxylate hydrochloride Chemical Structure

Ethyl azetidine-3-carboxylate hydrochloride Chemical Structure

CAS No. : 405090-31-5

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Based on 1 publication(s) in Google Scholar

Ethyl azetidine-3-carboxylate hydrochloride Related Antibodies

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Description

Ethyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Ethyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2]

IC50 & Target

Non-cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ethyl azetidine-3-carboxylate hydrochloride Related Antibodies
Molecular Weight

165.62

Formula

C6H12ClNO2
CAS No.
Unlabeled Cas

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1CNC1)OCC.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥98.0%

COA (243 KB) HNMR (133 KB)

Handling Instructions (2659 KB)
References
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Ethyl azetidine-3-carboxylate hydrochloride Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ethyl azetidine-3-carboxylate405090-31-5ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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