2. Metabolic Enzyme/Protease Apoptosis
  3. Fatty Acid Synthase (FASN) Apoptosis
  4. Fasnall

Fasnall is a selective fatty acid synthase (FASN) inhibitor with an IC50 of 3.71 μM. Fasnall induces apoptosis in HER2+ breast cancer cell lines. Fasnall shows potent anti-tumor activities.

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Fasnall Chemical Structure

Fasnall Chemical Structure

CAS No. : 929978-58-5

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10 mg USD 320 In-stock
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Based on 1 publication(s) in Google Scholar

Fasnall Related Antibodies

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Description

Fasnall is a selective fatty acid synthase (FASN) inhibitor with an IC50 of 3.71 μM. Fasnall induces apoptosis in HER2+ breast cancer cell lines. Fasnall shows potent anti-tumor activities[1].

IC50 & Target

IC50: 3.71 μM (human purified FASN activity)[1]
In Vitro

Fasnall potently blocks both acetate and glucose incorporation into total lipids, with IC50 values of 147 and 213 nM, respectively, in HepG2 cells[1].
Fasnall (50 μM; 24-120 h) inhibits proliferation in breast cancer cell lines[1].
Fasnall (25-100 μM; 24 h) induces apoptosis in HER2+ breast cancer cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fasnall Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MCF7, MDA-MB-468, BT474 and SKBR3 cells
Concentration: 50 μM
Incubation Time: 24 h, 48 h, 72 h, 96 h, 120 h
Result: Inhibited the proliferation of aggressive cell lines, but showed lower activity in the non-tumorigenic cell line MCF10A.

Apoptosis Analysis[1]

Cell Line: MCF7, MDA-MB-468, BT474 and SKBR3 cells
Concentration: 25 μM, 50 μM , 75 μM, 100 μM
Incubation Time: 24 h
Result: Induced caspase-3 and caspase-7 activation.
In Vivo

Fasnall (15 mg/kg, intraperitoneally, twice weekly; 3 weeks) shows potent anti-tumor activity in MMTV-Neu model of HER2+ breast cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female MMTV-NEU mice bearing HER2+ breast cancer cells[1]
Dosage: 15 mg/kg
Administration: i.p.; twice weekly; 3 weeks
Result: Reduced tumor volume, and increased the median survival of the MMTV-Neu mice to 63 days.
Molecular Weight

338.47

Formula

C19H22N4S
CAS No.
Unlabeled CAS

Appearance

Solid

Color

Light yellow to brown

SMILES

CC1=C(C2=C(N=CN=C2S1)NC3CN(CC3)CC4=CC=CC=C4)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (295.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9545 mL 14.7724 mL 29.5447 mL
5 mM 0.5909 mL 2.9545 mL 5.9089 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.54%

COA (251 KB) HNMR (246 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9545 mL 14.7724 mL 29.5447 mL 73.8618 mL
5 mM 0.5909 mL 2.9545 mL 5.9089 mL 14.7724 mL
10 mM 0.2954 mL 1.4772 mL 2.9545 mL 7.3862 mL
15 mM 0.1970 mL 0.9848 mL 1.9696 mL 4.9241 mL
20 mM 0.1477 mL 0.7386 mL 1.4772 mL 3.6931 mL
25 mM 0.1182 mL 0.5909 mL 1.1818 mL 2.9545 mL
30 mM 0.0985 mL 0.4924 mL 0.9848 mL 2.4621 mL
40 mM 0.0739 mL 0.3693 mL 0.7386 mL 1.8465 mL
50 mM 0.0591 mL 0.2954 mL 0.5909 mL 1.4772 mL
60 mM 0.0492 mL 0.2462 mL 0.4924 mL 1.2310 mL
80 mM 0.0369 mL 0.1847 mL 0.3693 mL 0.9233 mL
100 mM 0.0295 mL 0.1477 mL 0.2954 mL 0.7386 mL
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Fasnall Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fasnall929978-58-5Fatty Acid Synthase (FASN)ApoptosisFASN catalyzesthiophenopyrimidineanti-tumor activityapoptosis inducerInhibitorinhibitorinhibit

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