2. PI3K/Akt/mTOR
  3. PI3K mTOR
  4. FD274

FD274 is a highly potent PI3K/mTOR dual inhibitor with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM against PI3Kα/β/γ/δ and mTOR, respectively. FD274 exhibits significant anti-proliferation of AML cell lines (HL-60 and MOLM-16). FD274 demonstrates dose-dependent inhibition of tumor growth in the HL-60 xenograft model. FD274 has the potential for acute myeloid leukemia research.

For research use only. We do not sell to patients.

FD274 Chemical Structure

FD274 Chemical Structure

CAS No. : 2641899-38-7

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FD274 Related Antibodies

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Description

FD274 is a highly potent PI3K/mTOR dual inhibitor with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM against PI3Kα/β/γ/δ and mTOR, respectively. FD274 exhibits significant anti-proliferation of AML cell lines (HL-60 and MOLM-16). FD274 demonstrates dose-dependent inhibition of tumor growth in the HL-60 xenograft model. FD274 has the potential for acute myeloid leukemia research[1].

IC50 & Target[1]

PI3Kα

0.65 nM (IC50)

PI3Kβ

1.57 nM (IC50)

PI3Kδ

0.65 nM (IC50)

PI3Kγ

0.42 nM (IC50)

mTOR

2.03 nM (IC50)

Molecular Weight

480.90

Formula

C22H14ClFN6O2S
CAS No.
Unlabeled CAS

SMILES

ClC1=NC=C(C2=CN=C(NN=C3C4=CC=NC=C4)C3=C2)C=C1NS(=O)(C5=CC=C(F)C=C5)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FD274 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FD2742641899-38-7FD 274FD-274PI3KmTORPhosphoinositide 3-kinaseMammalian target of Rapamycinacute myeloid leukemiaanti-proliferationAMLHL-60MOLM-16Inhibitorinhibitorinhibit

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