2. Membrane Transporter/Ion Channel Neuronal Signaling Autophagy
  3. Calcium Channel Autophagy
  4. Felodipine-d3

Felodipine-d3 is the deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3].

For research use only. We do not sell to patients.

Felodipine-d<sub>3</sub> Chemical Structure

Felodipine-d3 Chemical Structure

CAS No. : 1219795-30-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Felodipine-d3:

Felodipine-d3 Related Antibodies

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  • Purity & Documentation

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Description

Felodipine-d3 is the deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Felodipine-d3 Related Antibodies
Molecular Weight

387.27

Formula

C18H16D3Cl2NO4
CAS No.
Unlabeled CAS

72509-76-3
Appearance

Solid

Color

White to off-white

SMILES

CCOC(C1=C(C)NC(C)=C(C(OC)=O)C1C2=C(C(Cl)=C([2H])C([2H])=C2[2H])Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (258.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5822 mL 12.9109 mL 25.8218 mL
5 mM 0.5164 mL 2.5822 mL 5.1644 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.10%

COA (256 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5822 mL 12.9109 mL 25.8218 mL 64.5544 mL
5 mM 0.5164 mL 2.5822 mL 5.1644 mL 12.9109 mL
10 mM 0.2582 mL 1.2911 mL 2.5822 mL 6.4554 mL
15 mM 0.1721 mL 0.8607 mL 1.7215 mL 4.3036 mL
20 mM 0.1291 mL 0.6455 mL 1.2911 mL 3.2277 mL
25 mM 0.1033 mL 0.5164 mL 1.0329 mL 2.5822 mL
30 mM 0.0861 mL 0.4304 mL 0.8607 mL 2.1518 mL
40 mM 0.0646 mL 0.3228 mL 0.6455 mL 1.6139 mL
50 mM 0.0516 mL 0.2582 mL 0.5164 mL 1.2911 mL
60 mM 0.0430 mL 0.2152 mL 0.4304 mL 1.0759 mL
80 mM 0.0323 mL 0.1614 mL 0.3228 mL 0.8069 mL
100 mM 0.0258 mL 0.1291 mL 0.2582 mL 0.6455 mL
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Felodipine-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Felodipine-d31219795-30-8Calcium ChannelAutophagyCa2+ channelsCa channelsInhibitorinhibitorinhibit

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