2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Flecainide-d4 acetate

Flecainide-d4 acetate  (Synonyms: R-818-d4)

Cat. No.: HY-17429S Purity: ≥99.0%
COA Handling Instructions

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Flecainide-d4 (acetate) is the deuterium labeled Flecainide acetate. Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential[1][2].

For research use only. We do not sell to patients.

Flecainide-d<sub>4</sub> acetate Chemical Structure

Flecainide-d4 acetate Chemical Structure

CAS No. : 1276197-21-7

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Based on 1 publication(s) in Google Scholar

Other Forms of Flecainide-d4 acetate:

Flecainide-d4 acetate Related Antibodies

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Description

Flecainide-d4 (acetate) is the deuterium labeled Flecainide acetate. Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Flecainide-d4 acetate Related Antibodies
Molecular Weight

478.42

Formula

C19H20D4F6N2O5
CAS No.
Unlabeled CAS

54143-56-5
Appearance

Solid

Color

White to off-white

SMILES

CC(O)=O.O=C(C1=C(C=CC(OC([2H])([2H])C(F)(F)F)=C1)OC([2H])([2H])C(F)(F)F)NCC2CCCCN2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (104.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 20 mg/mL (41.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0902 mL 10.4511 mL 20.9021 mL
5 mM 0.4180 mL 2.0902 mL 4.1804 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (249 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.0902 mL 10.4511 mL 20.9021 mL 52.2553 mL
5 mM 0.4180 mL 2.0902 mL 4.1804 mL 10.4511 mL
10 mM 0.2090 mL 1.0451 mL 2.0902 mL 5.2255 mL
15 mM 0.1393 mL 0.6967 mL 1.3935 mL 3.4837 mL
20 mM 0.1045 mL 0.5226 mL 1.0451 mL 2.6128 mL
25 mM 0.0836 mL 0.4180 mL 0.8361 mL 2.0902 mL
30 mM 0.0697 mL 0.3484 mL 0.6967 mL 1.7418 mL
40 mM 0.0523 mL 0.2613 mL 0.5226 mL 1.3064 mL
DMSO 50 mM 0.0418 mL 0.2090 mL 0.4180 mL 1.0451 mL
60 mM 0.0348 mL 0.1742 mL 0.3484 mL 0.8709 mL
80 mM 0.0261 mL 0.1306 mL 0.2613 mL 0.6532 mL
100 mM 0.0209 mL 0.1045 mL 0.2090 mL 0.5226 mL
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Flecainide-d4 acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flecainide-d41276197-21-7R-818-d4Sodium ChannelNa channelsNa+ channelsInhibitorinhibitorinhibit

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