Fluorescein-DBCO

Name: Fluorescein-DBCO
Brand: MedChemExpress
SKU: HY-126851
Rating: 4.5 (1 reviews)

Cat. No.: HY-126851 Purity: 95.53%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Fluorescein-DBCO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fluorescein-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Fluorescein-DBCO Chemical Structure

CAS No. : 2054339-00-1

Size	Price	Stock	Quantity
1 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 630	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 980	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Fluorescein-DBCO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. Fluorescein-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC₅₀ & Target

Non-cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

665.71

Formula

C₃₉H₂₇N₃O₆S

CAS No.

2054339-00-1

Unlabeled Cas

Appearance

Solid

Color

Yellow to orange

SMILES

O=C(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)CCNC(NC4=CC=C(C5=C4)C6(OC5=O)C7=C(OC8=C6C=CC(O)=C8)C=C(O)C=C7)=S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (150.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5022 mL	7.5108 mL	15.0216 mL
5 mM	0.3004 mL	1.5022 mL	3.0043 mL
10 mM	0.1502 mL	0.7511 mL	1.5022 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥96.0%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (252 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5022 mL	7.5108 mL	15.0216 mL	37.5539 mL
	5 mM	0.3004 mL	1.5022 mL	3.0043 mL	7.5108 mL
	10 mM	0.1502 mL	0.7511 mL	1.5022 mL	3.7554 mL
	15 mM	0.1001 mL	0.5007 mL	1.0014 mL	2.5036 mL
	20 mM	0.0751 mL	0.3755 mL	0.7511 mL	1.8777 mL
	25 mM	0.0601 mL	0.3004 mL	0.6009 mL	1.5022 mL
	30 mM	0.0501 mL	0.2504 mL	0.5007 mL	1.2518 mL
	40 mM	0.0376 mL	0.1878 mL	0.3755 mL	0.9388 mL
	50 mM	0.0300 mL	0.1502 mL	0.3004 mL	0.7511 mL
	60 mM	0.0250 mL	0.1252 mL	0.2504 mL	0.6259 mL
	80 mM	0.0188 mL	0.0939 mL	0.1878 mL	0.4694 mL
	100 mM	0.0150 mL	0.0751 mL	0.1502 mL	0.3755 mL