2. Stem Cell/Wnt
  3. Wnt
  4. Foxy-5

Foxy-5, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Foxy-5 TFA) that retains the same biological activity.

For research use only. We do not sell to patients.

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Foxy-5 Chemical Structure

Foxy-5 Chemical Structure

CAS No. : 881188-51-8

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Foxy-5 Related Antibodies

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Description

Foxy-5, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model[1][2][3].

IC50 & Target

WNT5A[2]
In Vitro

Foxy-5 (100 μM, 24 h) inhibits the invasion of tumor cells in DU145 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Foxy-5 Related Antibodies

Cell Invasion Assay[3]

Cell Line: DU145, PC3
Concentration: 100 μM
Incubation Time: 24 h
Result: Reduced DU145 cell invasion by 40%.
In Vivo

Foxy-5 (2 mg/kg intraperitoneally injected 9 times a day for 7-23 days) reduces the number of colon cancer stem cells in a mouse model of human colon cancer xenotransplantation[2].
Foxy-5 (2 mg/kg, intraperitoneal injection, once a day, for 3-9 weeks) significantly reduces the early metastasis and spread of WNT5A low DU145 prostate cancer cells in a mouse model of prostate cancer xenotransplantation[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A Xenograft Mouse Model of Human Colonic Cancer[2]
Dosage: 2 mg/kg
Administration: i.p. 9 times a day for 7-23 days
Result: Reduced the expression of ALDH, DCLK1 and COX-2.
Increased the expression of 15-PGDH.
Reduced the expression of the downstream β-catenin target ASCL2.
Animal Model: A Xenograft Mouse Model of Prostate Cancer [3]
Dosage: 2 mg/kg
Administration: i.p. once a day, for 3-9 weeks
Result: Reduced metastatic spread and the number of tumor cells in lymph nodes.
Clinical Trial
Molecular Weight

694.77

Formula

C26H42N6O12S2
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

Sequence

{For}-Met-Asp-Gly-Cys-Glu-Leu
Sequence Shortening

{For}-MDGCEL
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Purity & Documentation
References
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Foxy-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Foxy-5881188-51-8Foxy5Foxy 5Wntmimickingpeptideanti-metastaticmigrationinvasionprostatecancerInhibitorinhibitorinhibit

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