2. Others
  3. Fluorescent Dye
  4. Gd-NMC-3

Gd-NMC-3 is a near-infrared fluorescence/magnetic resonance (NIRF/MR) bimodal imaging probe. Gd-NMC-3 shows high resolution and sensitivity in tumor imaging with good biocompatibility, indicating huge application potential.

For research use only. We do not sell to patients.

Gd-NMC-3 Chemical Structure

Gd-NMC-3 Chemical Structure

CAS No. : 2678579-76-3

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Gd-NMC-3 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Gd-NMC-3 is a near-infrared fluorescence/magnetic resonance (NIRF/MR) bimodal imaging probe. Gd-NMC-3 shows high resolution and sensitivity in tumor imaging with good biocompatibility, indicating huge application potential[1].

In Vitro

Gd-NMC-3 shows the maximum excitation wavelength and emission wavelength are 755 and 792 nm, respectively. Both wavelengths are located in the near-infrared region[1].
Gd-NMC-3 acts as a bimodal imaging molecule, can be accumulated in tumor sites[1].
Gd-NMC-3 (50 μM; 24 h) can be internalized into cancer cells by OATPs and NTCP, indicating an excellent specificity to tumor tissues[1].
Gd-NMC-3 (6.25-800 μM, 24 h) exhibits significant fluorescence accumulation (with the optimal concentration of 100, 200 μM) and reasonable relaxation property (11.64 M/m/s) in tumors[1].
Gd-NMC-3 (6.25-100 μM, 48 h) displays low cytotoxicity and good biocompatibility[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gd-NMC-3 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HepG2 and LM3: human hepatocarcinoma cell line; L02: human hepatocyte cell line
Concentration: 6.25-100 μM
Incubation Time: 48 hours
Result: Resulted more than 90% cell viability maintained after 48 h.
In Vivo

Gd-NMC-3 (20 mg/kg; i.v.) holds an excellent tumor targeting ability, shows high resolution and sensitivity and provides real-time visual navigation in LM3 orthotopic and subcutaneous tumor models to guide the resection of tumors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HepG2 subcutaneous xenograft mice[1]
Dosage: 20 mg/kg
Administration: Intravenous injection; 1.5 h later dissected tumors
Result: Accumulated in the tumor after injection and produced stronger fluorescence intensity in tumor tissues.
Remained fluorescence signal longer than 1.5 h, and provided high-resolution images of the tumor tissues with a SNR of 4.32.
Animal Model: LM3 orthotopic mice[1]
Dosage: 20 mg/kg
Administration: Intravenous injection
Result: Decreased gradually the fluorescence intensity in LM3 orthotopic liver tumors after administration, whereas tumor-to-skin fluorescence ratios increased due to high accumulation and low clearance in tumor tissues.
Molecular Weight

1968.46

Formula

C77H116Gd2N14O22S2
CAS No.
Unlabeled CAS

Emission (Em)

800
Excitation (Ex)

780
SMILES

CC1(C)C(/C=C/C=C/C=C/C=C2N(CCCCS(=O)(O)=O)C(C=CC(C(NCCCCNC(CN(CCN(CCN3CC(O)=O)CC(O)=O)CCN(CC3)CC(O)=O)=O)=O)=C4)=C4C/2(C)C)=[N+](CCCCS(=O)([O-])=O)C5=C1C=C(C(NCCCCNC(CN6CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC6)=O)=O)C=C5.[Gd].[Gd]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Gd-NMC-3 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gd-NMC-32678579-76-3Fluorescent Dyenear-infraredmagnetic resonanceNIRF/MR imagingnear-infrared fluorescence/magnetic resonancebimodal imaging moleculelow cytotoxicitybiocompatibilityrelaxation propertyfluorescence accumulationmultimodality imagingcovalently coupledDCDSTCYGd-DOTAbutane diamineInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Gd-NMC-3
Cat. No.:
HY-150979
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.