2. Gene
  3. OTUB1 - OTU deubiquitinase, ubiquitin aldehyde binding 1 Gene

OTUB1 - OTU deubiquitinase, ubiquitin aldehyde binding 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as OTB1; OTU1; HSPC263

Gene ID: 55611 | Gene type: protein coding

About OTUB1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:63,986,438-63,998,412 (from NCBI)

This gene has 11 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 29.9), placenta (RPKM 22.0) and 25 other tissues.

Summary

The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

OTUB1 Products(1)

mRNA Protein Name
NM_017670.3 NP_060140.2 ubiquitin thioesterase OTUB1

OTUB1 Protein Structure

Peptidase_C65

Peptidase_C65: Peptidase C65 Otubain (42 - 271)

  • 0
  • 100
  • 200
  • 271 a.a.
Protein Preferred Names Protein Names

ubiquitin thioesterase OTUB1

OTU domain, ubiquitin aldehyde binding 1

Recombinant OTUB1 Proteins

Cat. No. Product Name Accession Purity
HY-P75952 OTUB1 Protein, Human (His) Q96FW1-1 (M1-K271) ≥95%

Related Diseases

Diseases Alias
Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-151563 OTUB1/USP8-IN-1 Inhibitor 98.02% Unkown
HY-143345 EN523 98.99% Unkown
HY-115878 NJH-2-057 Modulator 98.87% Unkown
HY-143344 NJH-2-056 Modulator 98.23% Unkown
HY-144999 LEB-03-146 / Unkown
HY-143340 LEB-03-145 / Unkown
HY-143342 LEB-03-144 / Unkown
HY-143343 LEB-03-153 / Unkown
HY-RS09869 OTUB1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus OTUB1 VGNC VGNC:32491
Felis catus OTUB1 VGNC VGNC:63999
Mus musculus OTUB1 MGD MGI:2147616
Canis familiaris OTUB1 VGNC VGNC:49784
Rattus norvegicus OTUB1 RGD RGD:1311329
Others OTUB1 NCBI