Glutaric acid-d₄

Name: Glutaric acid-d 4
Brand: MedChemExpress
SKU: HY-W008820S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-W008820S1 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Glutaric acid-d₄ is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].

For research use only. We do not sell to patients.

Glutaric acid-d<sub>4</sub> Chemical Structure

Glutaric acid-d₄ Chemical Structure

CAS No. : 19136-99-3

Size	Price	Stock	Quantity
25 mg	USD 53	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 85	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 135	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Glutaric acid-d₄:

Glutaric acid In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

136.14

Formula

C₅H₄D₄O₄

CAS No.

19136-99-3

Unlabeled CAS

110-94-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C([2H])([2H])CC([2H])([2H])C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H2O : ≥ 100 mg/mL (734.54 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.3454 mL	36.7269 mL	73.4538 mL
5 mM	1.4691 mL	7.3454 mL	14.6908 mL
10 mM	0.7345 mL	3.6727 mL	7.3454 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (247 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Yang SY, et, al. Production of glutaric acid from 5-aminovaleric acid by robust whole-cell immobilized with polyvinyl alcohol and polyethylene glycol. Enzyme Microb Technol. 2019 Sep;128:72-78. [Content Brief]

[3]. Boy N, et, al. Proposed recommendations for diagnosing and managing individuals with glutaric aciduria type I: second revision. J Inherit Metab Dis. 2017 Jan;40(1):75-101. [Content Brief]

[4]. Isasi E, et, al. Glutaric Acid Affects Pericyte Contractility and Migration: Possible Implications for GA-I Pathogenesis. Mol Neurobiol. 2019 Nov;56(11):7694-7707. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H2O	1 mM	7.3454 mL	36.7269 mL	73.4538 mL	183.6345 mL
	5 mM	1.4691 mL	7.3454 mL	14.6908 mL	36.7269 mL
	10 mM	0.7345 mL	3.6727 mL	7.3454 mL	18.3634 mL
	15 mM	0.4897 mL	2.4485 mL	4.8969 mL	12.2423 mL
	20 mM	0.3673 mL	1.8363 mL	3.6727 mL	9.1817 mL
	25 mM	0.2938 mL	1.4691 mL	2.9382 mL	7.3454 mL
	30 mM	0.2448 mL	1.2242 mL	2.4485 mL	6.1211 mL
	40 mM	0.1836 mL	0.9182 mL	1.8363 mL	4.5909 mL
	50 mM	0.1469 mL	0.7345 mL	1.4691 mL	3.6727 mL
	60 mM	0.1224 mL	0.6121 mL	1.2242 mL	3.0606 mL
	80 mM	0.0918 mL	0.4591 mL	0.9182 mL	2.2954 mL
	100 mM	0.0735 mL	0.3673 mL	0.7345 mL	1.8363 mL