2. Others
  3. Others
  4. HaXS8

HaXS8 is a dimerizer that can promote a covalent and irreversible intracellular dimerization of HaloTag and SNAP-tagged proteins of interest. HaXS8 does not interfere with PI3K/mTOR signaling.

For research use only. We do not sell to patients.

HaXS8 Chemical Structure

HaXS8 Chemical Structure

CAS No. : 2080306-25-6

Size Price Stock Quantity
2 mg USD 390 In-stock
5 mg USD 780 In-stock
10 mg USD 1250 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

HaXS8 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

HaXS8 is a dimerizer that can promote a covalent and irreversible intracellular dimerization of HaloTag and SNAP-tagged proteins of interest. HaXS8 does not interfere with PI3K/mTOR signaling[1][2].

In Vitro

HaXS8 promotes intracellular dimerization of Halo-GFP and SNAP-GFP fusion proteins reached >65%, and displays significant intracellular dimerization as low as 50 nM in HeLa cells[1].
HaXS8 (0.5 μM; 40 min) induces a rapid and efficient cross-linking of the membrane anchor and the iSH2 construct, and triggers the activation of the downstream targets PKB/Akt and mTOR in HEK293 cells[1].
HaXS8 (0.5 μM; 40 min) does not upregulate MAPK phosphorylation in HEK293 cells[1].
HaXS8 (0.5 μM; 1 h) does not interfere with PI3K/mTOR signaling in HEK293 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HaXS8 Related Antibodies
Molecular Weight

787.20

Formula

C35H43ClF4N6O8
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

NC1=NC2=C(C(OCC3=CC=C(C=C3)CNC(COC4=C(C(F)=C(C(F)=C4F)OCCOCCOCCOCCOCCCCCCCl)F)=O)=N1)N=CN2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

HaXS8 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HaXS82080306-25-6HaXS 8HaXS-8OthersdimerizerdimerizationHalo,TagSNAP-taggedInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
HaXS8
Cat. No.:
HY-131015
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.