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  3. IA9

IA9  (Synonyms: human TREM-2 182-190)

Cat. No.: HY-P10136 Purity: 98.36%
COA Handling Instructions

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IA9 (human TREM-2 182-190) is a TREM-2 inhibitor , and can diminish release of proinflammatory cytokines and dramatically suppressed joint inflammation and damage in collagen-Induced Arthritis (CIA) mice model.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

IA9 Chemical Structure

IA9 Chemical Structure

Size Price Stock Quantity
1 mg USD 65 In-stock
5 mg USD 160 In-stock
10 mg USD 255 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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IA9 Related Antibodies

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Description

IA9 (human TREM-2 182-190) is a TREM-2 inhibitor , and can diminish release of proinflammatory cytokines and dramatically suppressed joint inflammation and damage in collagen-Induced Arthritis (CIA) mice model[1].

Molecular Weight

1001.31

Formula

C51H88N10O10
Unlabeled CAS

Appearance

Solid

Color

White to off-white

Sequence

Ile-Phe-Leu-Ile-Lys-Ile-Leu-Ala-Ala
Sequence Shortening

IFLIKILAA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 22.22 mg/mL (22.19 mM; ultrasonic and adjust pH to 4 with 1 M HCL; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9987 mL 4.9935 mL 9.9869 mL
5 mM 0.1997 mL 0.9987 mL 1.9974 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.36%

COA (246 KB) RP-HPLC (110 KB) MS (222 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9987 mL 4.9935 mL 9.9869 mL 24.9673 mL
5 mM 0.1997 mL 0.9987 mL 1.9974 mL 4.9935 mL
10 mM 0.0999 mL 0.4993 mL 0.9987 mL 2.4967 mL
15 mM 0.0666 mL 0.3329 mL 0.6658 mL 1.6645 mL
20 mM 0.0499 mL 0.2497 mL 0.4993 mL 1.2484 mL
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IA9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IA9human TREM-2 182-190IA 9IA-9Otherstriggering receptors expressed on myeloid cellsTREM-1TREM-2inflammationinnate immunitymacrophagesrheumatoid arthritisInhibitorinhibitorinhibit

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