2. Autophagy Anti-infection Protein Tyrosine Kinase/RTK
  3. Autophagy Bcr-Abl c-Kit PDGFR SARS-CoV
  4. Imatinib-d3 hydrochloride

Imatinib-d3 hydrochloride  (Synonyms: STI571-d3 hydrochloride; CGP-57148B-d3 hydrochloride)

Cat. No.: HY-15463S2 Purity: 95.19%
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Imatinib-d3 (hydrochloride) is the deuterium labeled Imatinib. Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV.

For research use only. We do not sell to patients.

Imatinib-d<sub>3</sub> hydrochloride Chemical Structure

Imatinib-d3 hydrochloride Chemical Structure

CAS No. : 1134803-18-1

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Based on 1 publication(s) in Google Scholar

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Imatinib-d3 hydrochloride Related Antibodies

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Description

Imatinib-d3 (hydrochloride) is the deuterium labeled Imatinib. Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Imatinib-d3 hydrochloride Related Antibodies
Molecular Weight

496.62

Formula

C29H28D3N7O
CAS No.
Unlabeled CAS

152459-95-5
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC=C(C=C1)CN2CCN(CC2)C([2H])([2H])[2H])NC3=CC=C(C)C(NC4=NC=CC(C5=CN=CC=C5)=N4)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (25.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 10 mg/mL (20.14 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0136 mL 10.0681 mL 20.1361 mL
5 mM 0.4027 mL 2.0136 mL 4.0272 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.0136 mL 10.0681 mL 20.1361 mL 50.3403 mL
5 mM 0.4027 mL 2.0136 mL 4.0272 mL 10.0681 mL
10 mM 0.2014 mL 1.0068 mL 2.0136 mL 5.0340 mL
15 mM 0.1342 mL 0.6712 mL 1.3424 mL 3.3560 mL
20 mM 0.1007 mL 0.5034 mL 1.0068 mL 2.5170 mL
DMSO 25 mM 0.0805 mL 0.4027 mL 0.8054 mL 2.0136 mL
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Imatinib-d3 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Imatinib-d31134803-18-1STI571-d3CGP-57148B-d3AutophagyBcr-Ablc-KitPDGFRSARS-CoVSCFRCD117Platelet-derived growth factor receptorSARS coronavirusInhibitorinhibitorinhibit

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