2. Protein Tyrosine Kinase/RTK Anti-infection Autophagy
  3. Bcr-Abl PDGFR c-Kit SARS-CoV Autophagy
  4. Imatinib-d8

Imatinib-d8  (Synonyms: STI571-d8; CGP-57148B-d8)

Cat. No.: HY-15463S Purity: 99.85%
COA Handling Instructions

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Imatinib-d8 is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity[1][2].

For research use only. We do not sell to patients.

Imatinib-d<sub>8</sub> Chemical Structure

Imatinib-d8 Chemical Structure

CAS No. : 1092942-82-9

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1 mg USD 450 In-stock
5 mg USD 1150 In-stock
10 mg USD 1900 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Imatinib-d8:

Imatinib-d8 Related Antibodies

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1 Publications Citing Use of MCE Imatinib-d8

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Description

Imatinib-d8 is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity[1][2].

Molecular Weight

501.65

Formula

C29H23D8N7O
CAS No.
Unlabeled CAS

152459-95-5
Appearance

Solid

Color

White to light yellow

SMILES

O=C(NC1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1)C4=CC=C(CN5C([2H])([2H])C([2H])([2H])N(C)C([2H])([2H])C5([2H])[2H])C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (24.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 10 mg/mL (19.93 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9934 mL 9.9671 mL 19.9342 mL
5 mM 0.3987 mL 1.9934 mL 3.9868 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.9934 mL 9.9671 mL 19.9342 mL 49.8355 mL
5 mM 0.3987 mL 1.9934 mL 3.9868 mL 9.9671 mL
10 mM 0.1993 mL 0.9967 mL 1.9934 mL 4.9836 mL
15 mM 0.1329 mL 0.6645 mL 1.3289 mL 3.3224 mL
DMSO 20 mM 0.0997 mL 0.4984 mL 0.9967 mL 2.4918 mL
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Imatinib-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Imatinib-d81092942-82-9STI571-d8CGP-57148B-d8Bcr-AblPDGFRc-KitSARS-CoVAutophagyPlatelet-derived growth factor receptorSCFRCD117SARS coronavirusInhibitorinhibitorinhibit

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