2. Apoptosis
  3. Apoptosis
  4. Iodoacetyl-LC-biotin

Iodoacetyl-LC-biotin is a biotinylated electrophile probe that can be used to investigate the scope and characteristics of protein covalent binding to subcellular proteomes.

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Iodoacetyl-LC-biotin Chemical Structure

Iodoacetyl-LC-biotin Chemical Structure

CAS No. : 93285-75-7

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10 mg USD 150 In-stock
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Based on 1 publication(s) in Google Scholar

Iodoacetyl-LC-biotin Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Iodoacetyl-LC-biotin is a biotinylated electrophile probe that can be used to investigate the scope and characteristics of protein covalent binding to subcellular proteomes[1][2].

In Vitro

Iodoacetyl-LC-biotin (IAB) (50-200 μM; 6-24 h) increases LDH leakage in HEK293 cells in a time- and dose-dependant manner[1].
IAB (50-200 µM; 24 h) causes the release of cytochrome c from the mitochondria to the cytosol in HEK293 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Iodoacetyl-LC-biotin Related Antibodies
Molecular Weight

510.43

Formula

C18H31IN4O3S
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCCCCCNC(CI)=O)CCCC[C@H]1[C@](NC2=O)([H])[C@](N2)([H])CS1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (39.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9591 mL 9.7957 mL 19.5913 mL
5 mM 0.3918 mL 1.9591 mL 3.9183 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9591 mL 9.7957 mL 19.5913 mL 48.9783 mL
5 mM 0.3918 mL 1.9591 mL 3.9183 mL 9.7957 mL
10 mM 0.1959 mL 0.9796 mL 1.9591 mL 4.8978 mL
15 mM 0.1306 mL 0.6530 mL 1.3061 mL 3.2652 mL
20 mM 0.0980 mL 0.4898 mL 0.9796 mL 2.4489 mL
25 mM 0.0784 mL 0.3918 mL 0.7837 mL 1.9591 mL
30 mM 0.0653 mL 0.3265 mL 0.6530 mL 1.6326 mL
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Iodoacetyl-LC-biotin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Iodoacetyl-LC-biotin93285-75-7ApoptosisbiotinylatedelectrophileprobeInhibitorinhibitorinhibit

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