2. GPCR/G Protein
  3. Adenosine Receptor
  4. ISAM-140

ISAM-140 (22b) is a potent and highly selective A2B adenosine receptor antagonist with a Ki of 3.49 nM.

For research use only. We do not sell to patients.

ISAM-140 Chemical Structure

ISAM-140 Chemical Structure

CAS No. : 932191-62-3

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10 mg USD 140 In-stock
25 mg USD 240 In-stock
50 mg USD 380 In-stock
100 mg USD 600 In-stock
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Based on 1 publication(s) in Google Scholar

ISAM-140 Related Antibodies

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Description

ISAM-140 (22b) is a potent and highly selective A2B adenosine receptor antagonist with a Ki of 3.49 nM[1].

IC50 & Target

hA2B

3.49 nM (Ki)

In Vitro

ISAM-140 (22b) (0.1-100 µM) inhibits NECA (5'-N-ethylcarboxamido adenosine)-stimulated cAMP accumulation[1].
ISAM-140 shows a KB value of 27.00 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ISAM-140 Related Antibodies
Molecular Weight

337.37

Formula

C19H19N3O3
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(C)N=C2NC3=CC=CC=C3N2C1C4=CC=CO4)OC(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (14.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9641 mL 14.8205 mL 29.6410 mL
5 mM 0.5928 mL 2.9641 mL 5.9282 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9641 mL 14.8205 mL 29.6410 mL 74.1026 mL
5 mM 0.5928 mL 2.9641 mL 5.9282 mL 14.8205 mL
10 mM 0.2964 mL 1.4821 mL 2.9641 mL 7.4103 mL
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ISAM-140 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ISAM-140932191-62-3ISAM140ISAM 140Adenosine ReceptorP1 receptorhighly selectivecAMPInhibitorinhibitorinhibit

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HY-111082
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