2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRASG12D-IN-1

KRASG12D-IN-1 (compound 22) is a KRASG12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition.

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KRASG12D-IN-1 Chemical Structure

KRASG12D-IN-1 Chemical Structure

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1 mg USD 400 In-stock
5 mg USD 990 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

KRASG12D-IN-1 (compound 22) is a KRASG12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition[1].

Molecular Weight

632.65

Formula

C34H28D2F4N6O2
Unlabeled CAS

Appearance

Solid

Color

Off-white to light yellow

SMILES

FC1=C(C2=CN=C1C3=C4C(C#C)=C(C=CC4=CC(O)=C3)F)N=C(N=C2N5C[C@H](CC6)N[C@H]6C5)OC([2H])(C78CCCN7C/C(C8)=C(F)\F)[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 71.43 mg/mL (112.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5807 mL 7.9033 mL 15.8065 mL
5 mM 0.3161 mL 1.5807 mL 3.1613 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5807 mL 7.9033 mL 15.8065 mL 39.5163 mL
5 mM 0.3161 mL 1.5807 mL 3.1613 mL 7.9033 mL
10 mM 0.1581 mL 0.7903 mL 1.5807 mL 3.9516 mL
15 mM 0.1054 mL 0.5269 mL 1.0538 mL 2.6344 mL
20 mM 0.0790 mL 0.3952 mL 0.7903 mL 1.9758 mL
25 mM 0.0632 mL 0.3161 mL 0.6323 mL 1.5807 mL
30 mM 0.0527 mL 0.2634 mL 0.5269 mL 1.3172 mL
40 mM 0.0395 mL 0.1976 mL 0.3952 mL 0.9879 mL
50 mM 0.0316 mL 0.1581 mL 0.3161 mL 0.7903 mL
60 mM 0.0263 mL 0.1317 mL 0.2634 mL 0.6586 mL
80 mM 0.0198 mL 0.0988 mL 0.1976 mL 0.4940 mL
100 mM 0.0158 mL 0.0790 mL 0.1581 mL 0.3952 mL
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KRASG12D-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRASG12D-IN-1RasAsPC-1anti-tumorInhibitorinhibitorinhibit

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