L,L-Dityrosine  (Synonyms: o,o'-Dityrosine)

L,L-Dityrosine (o,o'-Dityrosine) is a constituent of acid hydrolysates of a number of biological materials, including the insect cuticular resilin^[1].

L,L-Dityrosine (o,o'-Dityrosine) is elevated in ventral midbrain and striatum of MPTP-treated mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

360.36

C₁₈H₂₀N₂O₆

63442-81-9

Solid

White to off-white

O=C(O)[C@@H](N)CC1=CC(C2=C(O)C=CC(C[C@H](N)C(O)=O)=C2)=C(O)C=C1

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Kungl AJ, et al. Molecular dynamics simulation of the rare amino acid LL-dityrosine and a dityrosine-containing peptide: comparison with time-resolved fluorescence. Biochim Biophys Acta. 1994 Dec 15;1201(3):345-52.  [Content Brief]

  [2]. S Pennathur, et al. Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease. J Biol Chem. 1999 Dec 3;274(49):34621-8.  [Content Brief]