2. Anti-infection
  3. Bacterial
  4. Lacto-N-tetraose

Lacto-N-tetraose is the significant core structure of human milk oligosaccharides (HMOs) naturally existing in human milk. Lacto-N-tetraose is consist of galactose, N-acetylglucosamine, and glucose moieties. Lacto-N-tetraose has prebiotic effect, immune regulatory effect, anti-inflammatory effects, intestinal cell responses regulatory effect, antibacterial activity and antiviral activity. Lacto-N-tetraose has been widely added to infant formula.

For research use only. We do not sell to patients.

Lacto-N-tetraose Chemical Structure

Lacto-N-tetraose Chemical Structure

CAS No. : 14116-68-8

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Lacto-N-tetraose Related Antibodies

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Description

Lacto-N-tetraose is the significant core structure of human milk oligosaccharides (HMOs) naturally existing in human milk. Lacto-N-tetraose is consist of galactose, N-acetylglucosamine, and glucose moieties. Lacto-N-tetraose has prebiotic effect, immune regulatory effect, anti-inflammatory effects, intestinal cell responses regulatory effect, antibacterial activity and antiviral activity. Lacto-N-tetraose has been widely added to infant formula[1].

In Vitro

HMOs exhibits antimicrobial and antibiofilm activity against Streptococcus agalactiae, antibiofilm activity against Methicillin-resistant Staphylococcus aureus (MRSA), and antimicrobial activity against both Acinetobacter baumannii and Clostridium difficile[2].
Lacto-N-tetraose (500-2000 μg/mL) does not cause clastogenic or aneugenic signs in human peripheral blood lymphocytes, nor increase the percentage of micronucleated cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lacto-N-tetraose Related Antibodies
In Vivo

Lacto-N-tetraose (1000-4000 mg/kg; p.o.; daily for 90 days) does not show toxicity in neonatal SD rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female neonatal SD rats (housed together with dam until weaning after 21 days)[3]
Dosage: 1000, 25000 and 4000 mg/kg 
Administration: p.o.; daily for 90 days
Result: Did not show toxicity on clinical observations, body weight, food consumption, development and maturation, clinical pathology, organ weights or histopathology.
Molecular Weight

707.63

Formula

C26H45NO21
CAS No.
Unlabeled Cas

SMILES

CC(N[C@H]([C@H]([C@@H]([C@H](O1)CO)O)O[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2O)O)O)CO)[C@@H]1O[C@@H]3[C@H]([C@@H](O[C@@H]([C@@H]3O)CO)O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O)=O
Structure Classification
Initial Source

human
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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Lacto-N-tetraose Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lacto-N-tetraose14116-68-8BacterialmilkoligosaccharidesHMOsprebioticimmuneanti-inflammatoryintestinal cellantibacterialantiviralInhibitorinhibitorinhibit

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