Lomefloxacin-d₅ hydrochloride

Name: Lomefloxacin-d 5 hydrochloride
Brand: MedChemExpress
SKU: HY-B0455S
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0455S Purity: 99.88%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Lomefloxacin-d₅ (hydrochloride) is the deuterium labeled Lomefloxacin hydrochloride. Lomefloxacin (SC47111A) hydrochloride is a broad-spectrum quinolone antibiotic, with antimicrobial activity. Lomefloxacin hydrochloride is used for the research of respiratory tract infections, genitourinary infections, gastrointestinal infections, ENT infections, etc.[1][2].

For research use only. We do not sell to patients.

Lomefloxacin-d<sub>5</sub> hydrochloride Chemical Structure

Lomefloxacin-d₅ hydrochloride Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 560	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Lomefloxacin-d₅ hydrochloride:

Lomefloxacin hydrochloride In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

392.84

Formula

C₁₇H₁₅D₅ClF₂N₃O₃

Unlabeled Cas

98079-52-8

Appearance

Solid

Color

White to off-white

SMILES

FC1=C(C2=CC(F)=C1N(CCN3)CC3C)N(C=C(C(O)=O)C2=O)C([2H])([2H])C([2H])([2H])[2H].Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H2O : 7.14 mg/mL (18.18 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5456 mL	12.7278 mL	25.4557 mL
5 mM	0.5091 mL	2.5456 mL	5.0911 mL
10 mM	0.2546 mL	1.2728 mL	2.5456 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.88%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (252 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Hoogkamp-Korstanje JA. In-vitro activities of ciprofloxacin, levofloxacin, lomefloxacin, ofloxacin, pefloxacin, sparfloxacin and trovafloxacin against gram-positive and gram-negative pathogens from respiratory tract infections. J Antimicrob Chemother. 1997 Sep;40(3):427-31. [Content Brief]

[2]. Reem I Al-Wabli. Lomefloxacin. Profiles Drug Subst Excip Relat Methodol. 2017;42:193-240. [Content Brief]

[3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H2O	1 mM	2.5456 mL	12.7278 mL	25.4557 mL	63.6391 mL
	5 mM	0.5091 mL	2.5456 mL	5.0911 mL	12.7278 mL
	10 mM	0.2546 mL	1.2728 mL	2.5456 mL	6.3639 mL
	15 mM	0.1697 mL	0.8485 mL	1.6970 mL	4.2426 mL