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  5. LQVTDSGLYRCVIYHPP

LQVTDSGLYRCVIYHPP (LP17) is a triggering receptor expressed on myeloid cells (TREM-1) inhibitory peptide. LQVTDSGLYRCVIYHPP substantially alleviates ischemia-induced infarction and neuronal injury. LQVTDSGLYRCVIYHPP can get access into brain and block TREM-1.

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LQVTDSGLYRCVIYHPP Chemical Structure

LQVTDSGLYRCVIYHPP Chemical Structure

CAS No. : 887255-16-5

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Based on 1 publication(s) in Google Scholar

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LQVTDSGLYRCVIYHPP Related Antibodies

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Description

LQVTDSGLYRCVIYHPP (LP17) is a triggering receptor expressed on myeloid cells (TREM-1) inhibitory peptide. LQVTDSGLYRCVIYHPP substantially alleviates ischemia-induced infarction and neuronal injury. LQVTDSGLYRCVIYHPP can get access into brain and block TREM-1[1].

IC50 & Target

TREM-1[1]
In Vitro

LQVTDSGLYRCVIYHPP (LP17) (1 or 10 μM; 24 h) substantially decreases mRNA levels of pro-inflammatory cytokines and chemokines after reoxygenation and remarkably attenuates extracellular protein levels of IL-1β and IL-18 in a microglia oxygen-glucose deprivation (OGD) model[1].
LQVTDSGLYRCVIYHPP (LP17) (10 μM; 24 h) interacts with microglial SYK[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LQVTDSGLYRCVIYHPP Related Antibodies

RT-PCR[1]

Cell Line: Primary microglia
Concentration: 1 or 10 μM
Incubation Time: 24 h
Result: Decreased mRNA levels of NLRP3, IL-1β, IL-18, IL-6, CD16, CD32, iNOS, MCP-1, CXCL-1, and CXCL-2 after reoxygenation.

Western Blot Analysis[1]

Cell Line: Primary microglia
Concentration: 10 μM
Incubation Time: 24 h
Result: Suppressed ischemia/reperfusion-induced increments in CARD9, p-p65 in CARD9/NF-κB signaling and NLRP3, ASC, cleaved caspase-1, mature IL-1β, and mature IL-18 in NLRP3/caspase-1 signaling in a microglia oxygen-glucose deprivation (OGD) model.
In Vivo

LQVTDSGLYRCVIYHPP (LP17) (0.5 or 1 mg/kg; intranasal; daily for 3 days) alleviates ischemia-induced infarction and neuronal injury in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male C57BL/6J mice (20-25 g), mice cerebral ischemia/reperfusion (I/R) model induced by middle cerebral artery occlusion (MCAO)[1]
Dosage: 0.5 mg/kg or 1 mg/kg
Administration: Intranasal administration, once daily for 3 consecutive days after MCAO
Result: Abolished ischemia-induced TREM-1 elevation at 1 mg/kg. Significantly reduced infarct volume by 27.3%, induced a markedly reduction in TUNEL positive cells and FJC positive neurons at 1 mg/kg. Rescued neurological deficits and cognitive dysfunction of MCAO mice. Inhibited microglial M1 polarization and neutrophil infiltration.
Molecular Weight

1961.24

Formula

C89H137N23O25S
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

Sequence Shortening

LQVTDSGLYRCVIYHPP
SMILES

O=C(N1[C@@H](CCC1)C(O)=O)[C@H]2N(CCC2)C([C@@H](NC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@H](C(C)C)NC([C@H](CS)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CC(C)C)NC(CNC([C@H](CO)NC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](C(C)C)NC([C@H](CCC(N)=O)NC([C@@H](N)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)CC3=CC=C(C=C3)O)=O)=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O)CC5=CN=CN5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (12.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 5 mg/mL (2.55 mM; ultrasonic and adjust pH to 2 with HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5099 mL 2.5494 mL 5.0988 mL
5 mM 0.1020 mL 0.5099 mL 1.0198 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.78%

COA (247 KB) LCMS (92 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 0.5099 mL 2.5494 mL 5.0988 mL 12.7470 mL
DMSO 5 mM 0.1020 mL 0.5099 mL 1.0198 mL 2.5494 mL
10 mM 0.0510 mL 0.2549 mL 0.5099 mL 1.2747 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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LQVTDSGLYRCVIYHPP Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LQVTDSGLYRCVIYHPP887255-16-5OthersTREM-1 inhibitory peptideischemia-induced infarctionneuronal injurynervous systemInhibitorinhibitorinhibit

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