2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Mabuterol

Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB.

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Mabuterol Chemical Structure

Mabuterol Chemical Structure

CAS No. : 56341-08-3

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Based on 1 publication(s) in Google Scholar

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Mabuterol Related Antibodies

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Description

Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB[1][2].

IC50 & Target[1][2]

Beta-2 adrenergic receptor

 

In Vitro

Mabuterol (10-60 µM; 48 h) inhibits the proliferation of ASMCs induced by PDGF-BB[2].
Mabuterol (50 µM; 1h) suppresses the increase of intracellular Ca2+ induced by PDGF-BB (25 ng/ml)[2].
Mabuterol (50 µM; 48 h) significantly suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mabuterol Related Antibodies

Cell Proliferation Assay[2]

Cell Line: rat ASMCs[2]
Concentration: 10, 20, 30, 40, 50, 60 µM
Incubation Time: 24, 48 h
Result: Inhibited the proliferation of ASMCs induced by PDGF-BB (25 ng/ml) in a dose-dependent maner at 48 h.
Molecular Weight

310.74

Formula

C13H18ClF3N2O
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

CC(NCC(O)C1=CC(C(F)(F)F)=C(N)C(Cl)=C1)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (402.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2181 mL 16.0906 mL 32.1812 mL
5 mM 0.6436 mL 3.2181 mL 6.4362 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2181 mL 16.0906 mL 32.1812 mL 80.4531 mL
5 mM 0.6436 mL 3.2181 mL 6.4362 mL 16.0906 mL
10 mM 0.3218 mL 1.6091 mL 3.2181 mL 8.0453 mL
15 mM 0.2145 mL 1.0727 mL 2.1454 mL 5.3635 mL
20 mM 0.1609 mL 0.8045 mL 1.6091 mL 4.0227 mL
25 mM 0.1287 mL 0.6436 mL 1.2872 mL 3.2181 mL
30 mM 0.1073 mL 0.5364 mL 1.0727 mL 2.6818 mL
40 mM 0.0805 mL 0.4023 mL 0.8045 mL 2.0113 mL
50 mM 0.0644 mL 0.3218 mL 0.6436 mL 1.6091 mL
60 mM 0.0536 mL 0.2682 mL 0.5364 mL 1.3409 mL
80 mM 0.0402 mL 0.2011 mL 0.4023 mL 1.0057 mL
100 mM 0.0322 mL 0.1609 mL 0.3218 mL 0.8045 mL
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Mabuterol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mabuterol56341-08-3Adrenergic ReceptorBeta ReceptorASMCsDrp-1cyclinD1PCNAPDGF-BBMfn-2Ca2+Inhibitorinhibitorinhibit

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