Mca-SEVKMDAEFRK(Dnp)RR-NH2 

Mca-SEVKMDAEFRK(Dnp)RR-NH2, containing the wild-type amyloid precursor protein (APP) beta-secretase cleavage site, is the substrate of thimet oligopeptidase (TOP). It is used for Alzheimer's disease research^[1].

others

2033.18

C₈₇H₁₂₉N₂₇O₂₈S

1802078-33-6

{Mca}-Ser-Glu-Val-Lys-Met-Asp-Ala-Glu-Phe-Arg-{Lys(Dnp)}-Arg-Arg-NH2

{Mca}-SEVKMDAEFR-{Lys(Dnp)}-RR-NH2

N=C(NCCC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CC(C1=CC=C(C=C1O2)OC)=CC2=O)=O)CO)=O)CCC(O)=O)=O)C(C)C)=O)CCCCN)=O)CCSC)=O)CC(O)=O)=O)C)=O)CCC(O)=O)=O)CC3=CC=CC=C3)=O)CCCNC(N)=N)=O)CCCCNC4=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C4)=O)CCCNC(N)=N)=O)C(N)=O)N

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. H Koike, et al. Thimet Oligopeptidase Cleaves the Full-Length Alzheimer Amyloid Precursor Protein at a β-Secretase Cleavage Site in COS Cells. J Biochem. 1999 Jul;126(1):235-42.  [Content Brief]