1. Academic Validation
  2. Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases

Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases

  • J Biol Chem. 2010 Apr 9;285(15):11061-7. doi: 10.1074/jbc.R109.072181.
Maurizio Renna 1 Maria Jimenez-Sanchez Sovan Sarkar David C Rubinsztein
Affiliations

Affiliation

  • 1 Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, United Kingdom.
Abstract

Many of the neurodegenerative diseases that afflict people are caused by intracytoplasmic aggregate-prone proteins. These include Parkinson disease, tauopathies, and polyglutamine expansion diseases such as Huntington disease. In Mendelian forms of these diseases, the mutations generally confer toxic novel functions on the relevant proteins. Thus, one potential strategy for dealing with these mutant proteins is to enhance their degradation. This can be achieved by up-regulating macroautophagy, which we will henceforth call Autophagy. In this minireview, we will consider the reasons why Autophagy up-regulation may be a powerful strategy for these diseases. In addition, we will consider some of the drugs and associated signaling pathways that can be used to induce Autophagy with these therapeutic aims in mind.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-100200
    99.92%, Autophagy Positive Regulator