2. Immunology/Inflammation
  3. COX
  4. Mefenamic acid-d4

Mefenamic acid-d4 is a deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively[1][2].

For research use only. We do not sell to patients.

Mefenamic acid-d<sub>4</sub> Chemical Structure

Mefenamic acid-d4 Chemical Structure

CAS No. : 1216745-79-7

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5 mg USD 550 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Mefenamic acid-d4 is a deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively[1][2].

IC50 & Target[1]

hCOX-1

40 nM (IC50)

hCOX-2

3 nM (IC50)

Molecular Weight

245.31

Formula

C15H11D4NO2
CAS No.
Unlabeled CAS

61-68-7
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=C(NC2=CC=CC(C)=C2C)C([2H])=C([2H])C([2H])=C1[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (407.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.1 mg/mL (0.41 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0765 mL 20.3824 mL 40.7647 mL
5 mM 0.8153 mL 4.0765 mL 8.1529 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0765 mL 20.3824 mL 40.7647 mL 101.9119 mL
5 mM 0.8153 mL 4.0765 mL 8.1529 mL 20.3824 mL
10 mM 0.4076 mL 2.0382 mL 4.0765 mL 10.1912 mL
15 mM 0.2718 mL 1.3588 mL 2.7176 mL 6.7941 mL
20 mM 0.2038 mL 1.0191 mL 2.0382 mL 5.0956 mL
25 mM 0.1631 mL 0.8153 mL 1.6306 mL 4.0765 mL
30 mM 0.1359 mL 0.6794 mL 1.3588 mL 3.3971 mL
40 mM 0.1019 mL 0.5096 mL 1.0191 mL 2.5478 mL
50 mM 0.0815 mL 0.4076 mL 0.8153 mL 2.0382 mL
60 mM 0.0679 mL 0.3397 mL 0.6794 mL 1.6985 mL
80 mM 0.0510 mL 0.2548 mL 0.5096 mL 1.2739 mL
100 mM 0.0408 mL 0.2038 mL 0.4076 mL 1.0191 mL
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Mefenamic acid-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mefenamic acid-d41216745-79-7COXCyclooxygenaseInhibitorinhibitorinhibit

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