Moracin P 

Moracin P is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin P reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin P has neuroprotective and anti-inflammatory effects^[1][2][3].

Moracin P enhances cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells with an EC₅₀ value of 10.4 μM. Moracin P reduces ROS production in OGD-induced cell death (IC₅₀ values of 1.9 μM). Consequently, reactive oxygen species (ROS) are overexpressed in OGD-induced cells and Moracin P reduces ROS induced by OGD in dosedependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

326.34

C₁₉H₁₈O₅

102841-46-3

Solid

White to off-white

O[C@@H]1CC2=C(OC1(C)C)C=C(OC(C3=CC(O)=CC(O)=C3)=C4)C4=C2

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Hak Ju Lee, et al. Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells. Arch Pharm Res. 2011 Aug;34(8):1373-80.  [Content Brief]

  [2]. Yan Xia, et al. HIF-1α inhibitors: synthesis and biological evaluation of novel moracin O and P analogues. Eur J Med Chem. 2011 Jun;46(6):2386-96.  [Content Brief]

  [3]. Besse Hardianti, et al. Anti-inflammatory compounds moracin O and P from Morus alba Linn. (Sohakuhi) target the NF‑κB pathway. Mol Med Rep. 2020 Dec;22(6):5385-5391.  [Content Brief]