2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. N-desmethyl Enzalutamide-d6

N-desmethyl Enzalutamide-d6  (Synonyms: N-desmethyl MDV 3100-d6)

Cat. No.: HY-70002AS Purity: 97.95%
COA Handling Instructions

Molarity Calculator

N-desmethyl Enzalutamide-d6 is a deuterium labeled N-desmethyl Enzalutamide. N-desmethyl Enzalutamide is an active metabolite of Enzalutamide. N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide[1].

For research use only. We do not sell to patients.

N-desmethyl Enzalutamide-d<sub>6</sub> Chemical Structure

N-desmethyl Enzalutamide-d6 Chemical Structure

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1 mg USD 750 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of N-desmethyl Enzalutamide-d6:

N-desmethyl Enzalutamide-d6 Related Antibodies

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Description

N-desmethyl Enzalutamide-d6 is a deuterium labeled N-desmethyl Enzalutamide. N-desmethyl Enzalutamide is an active metabolite of Enzalutamide. N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide[1].

IC50 & Target

Androgen-receptor[1]
Molecular Weight

456.45

Formula

C20H8D6F4N4O2S
Appearance

Solid

Color

White to off-white

SMILES

S=C(N1C2=CC(F)=C(C(N)=O)C=C2)N(C3=CC=C(C(C(F)(F)F)=C3)C#N)C(C(C([2H])([2H])[2H])1C([2H])([2H])[2H])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (219.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1908 mL 10.9541 mL 21.9082 mL
5 mM 0.4382 mL 2.1908 mL 4.3816 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.95%

COA (254 KB) HNMR (129 KB) LCMS (90 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1908 mL 10.9541 mL 21.9082 mL 54.7705 mL
5 mM 0.4382 mL 2.1908 mL 4.3816 mL 10.9541 mL
10 mM 0.2191 mL 1.0954 mL 2.1908 mL 5.4771 mL
15 mM 0.1461 mL 0.7303 mL 1.4605 mL 3.6514 mL
20 mM 0.1095 mL 0.5477 mL 1.0954 mL 2.7385 mL
25 mM 0.0876 mL 0.4382 mL 0.8763 mL 2.1908 mL
30 mM 0.0730 mL 0.3651 mL 0.7303 mL 1.8257 mL
40 mM 0.0548 mL 0.2739 mL 0.5477 mL 1.3693 mL
50 mM 0.0438 mL 0.2191 mL 0.4382 mL 1.0954 mL
60 mM 0.0365 mL 0.1826 mL 0.3651 mL 0.9128 mL
80 mM 0.0274 mL 0.1369 mL 0.2739 mL 0.6846 mL
100 mM 0.0219 mL 0.1095 mL 0.2191 mL 0.5477 mL
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N-desmethyl Enzalutamide-d6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-desmethyl Enzalutamide-d6N-desmethyl MDV 3100-d6Androgen ReceptorDeuteriumlabeledmetaboliteEnzalutamidepharmacodynamicscirculatesCYP2C8CYP3A4Inhibitorinhibitorinhibit

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