NVOC cage-TMP-Halo

Name: NVOC cage-TMP-Halo
Brand: MedChemExpress
SKU: HY-153890
Rating: 4.5 (1 reviews)

Cat. No.: HY-153890 Purity: 96.04%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

NVOC cage-TMP-Halo is a cell-permeable and photoactivatable protein dimerization inducer. NVOC cage-TMP-Halo can rapidly and reversibly control protein localization in living cells. NVOC cage-TMP-Halo can be used for dynamic cellular processes research.

For research use only. We do not sell to patients.

NVOC cage-TMP-Halo Chemical Structure

CAS No. : 2137894-98-3

Size	Price	Stock	Quantity
1 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 270	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

NVOC cage-TMP-Halo (20μM, 60 min) exhibited dramatic recruitment of mCherry-eDHFR to centromeres with a t_1/2 of ~ 15 s of expressing CENPB-GFP-Haloenzyme and mCherry-eDHFR HeLa cell line^[1].
NVOC cage-TMP-Halo (20μM, 15, 30, and 60 min) has the power for spatially precise manipulation of protein localization in HeLa cell line^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

878.36

Formula

C₄₀H₅₆ClN₇O₁₃

CAS No.

2137894-98-3

Unlabeled CAS

Appearance

Solid

Color

Off-white to light yellow

SMILES

COC1=C(OC)C=C(COC(NC2=NC(N)=C(CC3=CC(OC)=C(OCCCNC(CCC(NCCOCCOCCCCCCCl)=O)=O)C(OC)=C3)C=N2)=O)C([N+]([O-])=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 150 mg/mL (170.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1385 mL	5.6924 mL	11.3849 mL
5 mM	0.2277 mL	1.1385 mL	2.2770 mL
10 mM	0.1138 mL	0.5692 mL	1.1385 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.04%

Select Batch:

Data Sheet (266 KB) SDS (251 KB)

COA (242 KB) HNMR (318 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Ballister ER, et al. Localized light-induced protein dimerization in living cells using a photocaged dimerizer. Nat Commun. 2014 Nov 17;5:5475. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1385 mL	5.6924 mL	11.3849 mL	28.4621 mL
	5 mM	0.2277 mL	1.1385 mL	2.2770 mL	5.6924 mL
	10 mM	0.1138 mL	0.5692 mL	1.1385 mL	2.8462 mL
	15 mM	0.0759 mL	0.3795 mL	0.7590 mL	1.8975 mL
	20 mM	0.0569 mL	0.2846 mL	0.5692 mL	1.4231 mL
	25 mM	0.0455 mL	0.2277 mL	0.4554 mL	1.1385 mL
	30 mM	0.0379 mL	0.1897 mL	0.3795 mL	0.9487 mL
	40 mM	0.0285 mL	0.1423 mL	0.2846 mL	0.7116 mL
	50 mM	0.0228 mL	0.1138 mL	0.2277 mL	0.5692 mL
	60 mM	0.0190 mL	0.0949 mL	0.1897 mL	0.4744 mL
	80 mM	0.0142 mL	0.0712 mL	0.1423 mL	0.3558 mL
	100 mM	0.0114 mL	0.0569 mL	0.1138 mL	0.2846 mL