2. GPCR/G Protein
  3. Taste Receptor
  4. Nα,Nα-Bis(carboxymethyl)-L-lysine

Nα,Nα-Bis(carboxymethyl)-L-lysine 

Cat. No.: HY-100047 Assay: 95.50%
COA Handling Instructions

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Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study.

For research use only. We do not sell to patients.

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Nα,Nα-Bis(carboxymethyl)-L-lysine Chemical Structure

Nα,Nα-Bis(carboxymethyl)-L-lysine Chemical Structure

CAS No. : 113231-05-3

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Based on 1 publication(s) in Google Scholar

Nα,Nα-Bis(carboxymethyl)-L-lysine Related Antibodies

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Description

Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study[1][2][3].

In Vitro

Nα,Nα-Bis(carboxymethyl)-L-lysine (59 nM) decreases the basal activity of H214A (constitutively active mutant of T2R4) by 40%[1].
Nα,Nα-Bis(carboxymethyl)-L-lysine (60 nM, 15 mins) blocks the decrease of basal activation state of Rac1 caused by quinine in HEK293T cells overexpressing T2R4 and Ga16/44, but has no effect in HEK293T control cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nα,Nα-Bis(carboxymethyl)-L-lysine Related Antibodies
In Vivo

Nα,Nα-Bis(carboxymethyl)-L-lysine (10 μM) has no effect on lick responses to bitter compounds in adult C57BL6/J[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

262.26

Formula

C10H18N2O6
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 1.82 mg/mL (6.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8130 mL 19.0650 mL 38.1301 mL
5 mM 0.7626 mL 3.8130 mL 7.6260 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (247 KB) HNMR (130 KB) LCMS (270 KB) OR (211 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8130 mL 19.0650 mL 38.1301 mL 95.3252 mL
5 mM 0.7626 mL 3.8130 mL 7.6260 mL 19.0650 mL
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Nα,Nα-Bis(carboxymethyl)-L-lysine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nα,Nα-Bis(carboxymethyl)-L-lysine113231-05-3Taste ReceptorRac1 GTPaseBitter taste receptorsLick responsesInhibitorinhibitorinhibit

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