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  4. Orforglipron hemicalcium hydrate

Orforglipron hemicalcium hydrate  (Synonyms: LY3502970 hemicalcium hydrate; GLP-1 receptor agonist 1 hemicalcium hydrate)

Cat. No.: HY-112185A Purity: 99.48%
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Orforglipron hemicalcium hydrate (LY3502970 hemicalcium hydrate; GLP-1 receptor agonist 1 hemicalcium hydrate) is the calcium salt hydrate form of Orforglipron (HY-112185). Orforglipron is an orally active agonist for Glucagon-like peptide-1 receptor (GLP-1R), which exhibits potency in ameliorating the type 2 diabete.

For research use only. We do not sell to patients.

Orforglipron hemicalcium hydrate Chemical Structure

Orforglipron hemicalcium hydrate Chemical Structure

CAS No. : 3008544-96-2

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5 mg USD 462 In-stock
10 mg USD 833 In-stock
25 mg USD 2000 In-stock
50 mg USD 3600 In-stock
100 mg USD 6493 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Orforglipron hemicalcium hydrate:

Orforglipron hemicalcium hydrate Related Antibodies

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1 Publications Citing Use of MCE Orforglipron hemicalcium hydrate

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Description

Orforglipron hemicalcium hydrate (LY3502970 hemicalcium hydrate; GLP-1 receptor agonist 1 hemicalcium hydrate) is the calcium salt hydrate form of Orforglipron (HY-112185). Orforglipron is an orally active agonist for Glucagon-like peptide-1 receptor (GLP-1R), which exhibits potency in ameliorating the type 2 diabete[1].

In Vivo

Orforglipron hemicalcium hydrate (0.94-4.8 nM in plasma concentration, i.v., or 0.05-0.1 mg/mL, i.g. for 5 days) suppresses food intake in a dose-dependent manner, promotes insulin secretion and blood glucose reduction in cynomolgus monkey model[1].
Orforglipron hemicalcium hydrate (0.05-1.35 mg/kg, i.g.) reaches Cmax 2 hours after administration at all doses, exhibits proportional ratio of increase in plasma drug exposure to dose increase, indicates a dose-dependent absorption in the gastrointestinal tract[1].

Pharmacokinetic Analysis of Orforglipron hemicalcium hydrate in cynomolgus monkey [1]

route Dose (mg/kg) Tmax (h) Cmax (ng/mL) AUC0-24h (ng·h/mL)
i.g. 0.05 2.0 4.78 23.7
i.g. 0.15 2.0 20.7 135
i.g. 0.45 2.0 32.0 208
i.g. 1.35 2.0 148 1040

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: cynomolgus monkey model[1]
Dosage: 0.9-4.8 nM; or 0.05-0.1 mg/mL
Administration: continuous i.v. administration for 30 minutes until a plasma concentration of 0.9-4.8 nM at steady state;
i.g. for 5 days with dose of 0.05-0.1 mg/mL
Result: Increased insulin secretion and decreased plasma-glucose.
Suppressed food intake in a dose-dependent manner.
Molecular Weight

921.02

Formula

C48H48F2N10O5.1/2Ca.H2O
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

C[C@@H]1[C@](N2C3=CC=C([C@]4([H])CC(C)(OCC4)C)C=C3C=C2C(N5[C@H](C6=C(N7C(N(C8=CC=C(N(N=C9)C)C9=C8F)C=C7)=O)N(C%10=CC(C)=C(C(C)=C%10)F)N=C6CC5)C)=O)(C(N%11)=NOC%11=O)C1.[0.5].[Ca].O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (27.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0858 mL 5.4288 mL 10.8575 mL
5 mM 0.2172 mL 1.0858 mL 2.1715 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0858 mL 5.4288 mL 10.8575 mL 27.1438 mL
5 mM 0.2172 mL 1.0858 mL 2.1715 mL 5.4288 mL
10 mM 0.1086 mL 0.5429 mL 1.0858 mL 2.7144 mL
15 mM 0.0724 mL 0.3619 mL 0.7238 mL 1.8096 mL
20 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.3572 mL
25 mM 0.0434 mL 0.2172 mL 0.4343 mL 1.0858 mL
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Orforglipron hemicalcium hydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Orforglipron hemicalcium3008544-96-2LY3502970 hemicalciumGLP-1 receptor agonist 1 hemicalciumGCGRGlucagon Receptortype 2 diabetecynomolgus monkeyInhibitorinhibitorinhibit

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