OSK-1 

OSK-1 is a potent K_v channel blocker with IC₅₀s of of 0.6 nM, 5.4 nM, 0.014 nM for K_v1.1, K_v1.2 and K_v1.3, respectively. OSK1 is a moderate blocker of Ca²⁺-activated K_Ca3.1 channel with an IC₅₀ of 225 nM. OSK-1 belongs to α-KTx3 toxins and is used as a immunosuppressive agent^[1].

IC50: 0.6 nM (K_v1.1), 5.4 nM (K_v1.2), 0.014 nM (K_v1.3) and 225 nM (K_Ca3.1)^[1]

OSK1 has no effect on K_Ca2.1, K_Ca2.2, K_Ca2.3 and K_Ca1.1 channels when in the micromolar concentration range, whereas it shows a moderate activity on K_Ca3.1 channel (also referred to as IK1 or SK4) with an IC₅₀ value of 225 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

OSK1 is lethal in mice by intracerebroventricular injection, with a LD₅₀ (50% lethal dose) value of 2 μg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4205.17

C₁₇₇H₃₀₀N₅₆O₄₆S₈

183815-75-0

O=C1NC(CCCCCC(C2OC2)O)C(NC(C)(C)C(NC(CC3=CC=CC=C3)C(N4CCCC14)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Stéphanie Mouhat, et al. K⁺ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom. Biochem J. 2005 Jan 1;385(Pt 1):95-104.  [Content Brief]