Peceleganan (Synonyms: PL-5)

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Peceleganan (PL-5) is an artificial antimicrobial cecropin A (1-10) × melittin B (3-18) hybrid (10+16)-peptide analogue. Peceleganan inhibits wound infection.

For research use only. We do not sell to patients.

Peceleganan Chemical Structure

CAS No. : 850761-47-6

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Description

Peceleganan (PL-5) is an artificial antimicrobial cecropin A (1-10) × melittin B (3-18) hybrid (10+16)-peptide analogue. Peceleganan inhibits wound infection^[1].

In Vitro

Peceleganan (24 h) shows antibacterial activity with MICs of 2, 2, 4, 4, 4 and 8 μM against E. coli ATCC 25922, S. pneumonia ATCC 49619, K. pneumonia ATCC 700603, S. aureus ATCC 25923, S. epidermidis ATCC 12228 and P. aeruginosa ATCC 27853, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Peceleganan (0.4 and 0.75 mg/mL for 100 μL; transdermal; twice daily for 3 days) inhibits Staphylococcus aureus in the mouse infection model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	ICR male mice (20-25 g), S. aureus ATCC 25923 wound infection model^[2]
Dosage:	0.4 and 0.75 mg/mL for 100 μL
Administration:	Transdermal administration, twice daily for 3 days
Result:	Significantly reduced the amount of bacteria.

Molecular Weight

2933.50

Formula

C₁₃₈H₂₂₆N₃₆O₃₄

CAS No.

850761-47-6

Unlabeled CAS

Sequence Shortening

Ac-KWKSFLKTFKSAAKTVLHTALKAISS-NH2

SMILES

[Ac-KWKSFLKTFKSAAKTVLHTALKAISS-NH2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. WHO Drug Information. International Nonproprietary Names for Pharmaceutical.

[2]. Feng Q, et al. Functional synergy of α-helical antimicrobial peptides and traditional antibiotics against Gram-negative and Gram-positive bacteria in vitro and in vivo. Eur J Clin Microbiol Infect Dis. 2015 Jan;34(1):197-204. [Content Brief]

Peceleganan Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Peceleganan850761-47-6PL-5PL5PL 5Bacterialantimicrobialcecropin Amelittin Bwound infectionInhibitorinhibitorinhibit

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