PKI (14-24)amide TFA

Name: PKI (14-24)amide TFA
Brand: MedChemExpress
SKU: HY-P3929A
Rating: 4.5 (1 reviews)

Cat. No.: HY-P3929A Purity: 98.69%: FAQs
Data Sheet SDS COA Handling Instructions

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PKI (14-24)amide TFA is a potent PKA inhibitor. PKI (14-24)amide strongly inhibited cyclic AMP-dependent protein kinase activity in the cell homogenate.

For research use only. We do not sell to patients.

PKI (14-24)amide TFA Chemical Structure

CAS No. : 1293946-39-0

Size	Price	Stock	Quantity
1 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of PKI (14-24)amide TFA:

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Biological Activity
Purity & Documentation
References
Customer Review

Description

PKI (14-24)amide TFA is a potent PKA inhibitor. PKI (14-24)amide strongly inhibited cyclic AMP-dependent protein kinase activity in the cell homogenate^[1]^[2].

In Vitro

PKI (14-24)amide TFA does not inhibit cyclic AMP-evoked amylase release from saponin-permeabilized cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1251.36 (free base)

Formula

C₄₉H₈₆N₂₄O₁₅.xC₂HF₃O₂

CAS No.

1293946-39-0

Unlabeled CAS

Appearance

Solid

Color

White to off-white

Sequence

Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-NH2

Sequence Shortening

GRTGRRNAIHD-NH2

SMILES

N=C(N)NCCC[C@H](NC(CN)=O)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(N[C@H](C(N)=O)CC(O)=O)=O)CC1=CN=CN1)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O.[x]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.69%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (250 KB) LCMS (96 KB) Elemental Analysis Report (109 KB)

Handling Instructions (2659 KB)

References

[1]. Nörenberg W, et al. Adenosine A2A receptors inhibit the conductance of NMDA receptor channels in rat neostriatal neurons. Amino Acids. 1998;14(1-3):33-9. [Content Brief]

[2]. Takuma T. Evidence against direct involvement of cyclic AMP-dependent protein phosphorylation in the exocytosis of amylase. Biochem J. 1988 Dec 15;256(3):867-71. [Content Brief]