(+)-Coclaurine hydrochloride  (Synonyms: (+)-(R)-Coclaurine hydrochloride; (R)-Coclaurine hydrochloride; d-Coclaurine hydrochloride)

(+)-Coclaurine ((+)-(R)-Coclaurine) hydrochloride, benzyltetrahydroisoquinoline alkaloid isolated from a variety of plant sources. (+)-Coclaurine hydrochloride has anti-aging activity^[1][2].

An intracerebroventricular injection of (+)-Coclaurine (d-Coclaurine; 50 μg) hydrochloride produces a slight increase in 3,4-dihydroxyphenylacetic acid level and a significant increase in homovanillic acid level in the mouse striatum. (+)-Coclaurine hydrochloride blocks postsynaptic but not presynaptic dopamine receptors in the mouse striatum^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

321.80

C₁₇H₂₀ClNO₃

19894-19-0

Solid

White to off-white

COC(C=C(CCN1)C([C@H]1CC2=CC=C(C=C2)O)=C3)=C3O.Cl

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. [1]Siva S Panda, et al. Protective effects of Aporosa octandra bark extract against D-galactose induced cognitive impairment and oxidative stress in mice. Heliyon. 2018 Nov 30;4(11):e00951.  [Content Brief]

  [2]. H Watanabe, et al. Effects of d-coclaurine and d-reticuline, benzyltetrahydroisoquinoline alkaloids, on levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid in the mouse striatum. J Pharmacobiodyn. 1983 Oct;6(10):793-6.  [Content Brief]