2. Cell Cycle/DNA Damage
  3. Poly(ADP-ribose) Glycohydrolase (PARG)
  4. pNP-ADPr disodium

pNP-ADPr disodium  (Synonyms: ADP-ribose-pNP disodium)

Cat. No.: HY-134354A Purity: 99.93%
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pNP-ADPr disodium is a colorimetric substrate that used for the first continuous Poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3) activity assays. pNP-ADPr disodium can be used for the research of poly(ADP-ribose)polymerase (PARP) enzymes.

For research use only. We do not sell to patients.

pNP-ADPr disodium Chemical Structure

pNP-ADPr disodium Chemical Structure

Size Price Stock Quantity
1 mg USD 620 In-stock
5 mg USD 1380 In-stock
10 mg USD 2200 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of pNP-ADPr disodium:

pNP-ADPr disodium Related Antibodies

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Description

pNP-ADPr disodium is a colorimetric substrate that used for the first continuous Poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3) activity assays. pNP-ADPr disodium can be used for the research of poly(ADP-ribose)polymerase (PARP) enzymes[1][2].

In Vitro

pNP-ADPr is a colorimetric substrate that used for the first continuous Poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3) activity assays[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

pNP-ADPr disodium Related Antibodies
Molecular Weight

724.37

Formula

C21H24N6Na2O16P2
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]1COP(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H](OC5=CC=C([N+]([O-])=O)C=C5)O4)(O[Na])=O)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (345.13 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3805 mL 6.9025 mL 13.8051 mL
5 mM 0.2761 mL 1.3805 mL 2.7610 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3805 mL 6.9025 mL 13.8051 mL 34.5127 mL
5 mM 0.2761 mL 1.3805 mL 2.7610 mL 6.9025 mL
10 mM 0.1381 mL 0.6903 mL 1.3805 mL 3.4513 mL
15 mM 0.0920 mL 0.4602 mL 0.9203 mL 2.3008 mL
20 mM 0.0690 mL 0.3451 mL 0.6903 mL 1.7256 mL
25 mM 0.0552 mL 0.2761 mL 0.5522 mL 1.3805 mL
30 mM 0.0460 mL 0.2301 mL 0.4602 mL 1.1504 mL
40 mM 0.0345 mL 0.1726 mL 0.3451 mL 0.8628 mL
50 mM 0.0276 mL 0.1381 mL 0.2761 mL 0.6903 mL
60 mM 0.0230 mL 0.1150 mL 0.2301 mL 0.5752 mL
80 mM 0.0173 mL 0.0863 mL 0.1726 mL 0.4314 mL
100 mM 0.0138 mL 0.0690 mL 0.1381 mL 0.3451 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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pNP-ADPr disodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

pNP-ADPr disodiumADP-ribose-pNP disodiumPoly(ADP-ribose) Glycohydrolase (PARG)Inhibitorinhibitorinhibit

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