2. PROTAC Apoptosis
  3. Ligands for E3 Ligase Molecular Glues Apoptosis
  4. Pomalidomide-d3

Pomalidomide-d3  (Synonyms: CC-4047-d3)

Cat. No.: HY-10984S1 Purity: ≥99.0%
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Pomalidomide-d3 is the deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors[1][2].

For research use only. We do not sell to patients.

Pomalidomide-d<sub>3</sub> Chemical Structure

Pomalidomide-d3 Chemical Structure

CAS No. : 2093128-28-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Pomalidomide-d3:

Pomalidomide-d3 Related Antibodies

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Description

Pomalidomide-d3 is the deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pomalidomide-d3 Related Antibodies
Molecular Weight

276.26

Formula

C13H8D3N3O4
CAS No.
Unlabeled CAS

19171-19-8
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N(C2C(NC(CC2)=O)=O)C(C3=C(N)C([2H])=C([2H])C([2H])=C31)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (180.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6198 mL 18.0989 mL 36.1978 mL
5 mM 0.7240 mL 3.6198 mL 7.2396 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6198 mL 18.0989 mL 36.1978 mL 90.4945 mL
5 mM 0.7240 mL 3.6198 mL 7.2396 mL 18.0989 mL
10 mM 0.3620 mL 1.8099 mL 3.6198 mL 9.0494 mL
15 mM 0.2413 mL 1.2066 mL 2.4132 mL 6.0330 mL
20 mM 0.1810 mL 0.9049 mL 1.8099 mL 4.5247 mL
25 mM 0.1448 mL 0.7240 mL 1.4479 mL 3.6198 mL
30 mM 0.1207 mL 0.6033 mL 1.2066 mL 3.0165 mL
40 mM 0.0905 mL 0.4525 mL 0.9049 mL 2.2624 mL
50 mM 0.0724 mL 0.3620 mL 0.7240 mL 1.8099 mL
60 mM 0.0603 mL 0.3016 mL 0.6033 mL 1.5082 mL
80 mM 0.0452 mL 0.2262 mL 0.4525 mL 1.1312 mL
100 mM 0.0362 mL 0.1810 mL 0.3620 mL 0.9049 mL
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Pomalidomide-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-d32093128-28-8CC-4047-d3Ligands for E3 LigaseMolecular GluesApoptosisE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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