Thalidomide-4-O-C2-NH2 hydrochloride

Name: Thalidomide-4-O-C2-NH2 hydrochloride
Brand: MedChemExpress
SKU: HY-136162
Rating: 4.5 (1 reviews)

Cat. No.: HY-136162 Purity: 99.37%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Thalidomide-4-O-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-4-O-C2-NH2 hydrochloride Chemical Structure

CAS No. : 2341840-99-9

Size	Price	Stock	Quantity
5 mg	USD 64	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

View All Isoforms

Biological Activity
Purity & Documentation
References
Customer Review

Description

Thalidomide-4-O-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology^[1].

IC₅₀ & Target^[1]

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

353.76

Formula

C₁₅H₁₆ClN₃O₅

CAS No.

2341840-99-9

Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCN)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (353.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8268 mL	14.1339 mL	28.2678 mL
5 mM	0.5654 mL	2.8268 mL	5.6536 mL
10 mM	0.2827 mL	1.4134 mL	2.8268 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.37%

Select Batch:

Data Sheet (273 KB) SDS (644 KB)

COA (251 KB) HNMR (281 KB) LCMS (89 KB)

Handling Instructions (2659 KB)

References

[1]. Turk BE, et al. Binding of thalidomide to alpha1-acid glycoprotein may be involved in its inhibition of tumor necrosis factor alpha production. Proc Natl Acad Sci U S A. 1996;93(15):7552‐7556. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8268 mL	14.1339 mL	28.2678 mL	70.6694 mL
	5 mM	0.5654 mL	2.8268 mL	5.6536 mL	14.1339 mL
	10 mM	0.2827 mL	1.4134 mL	2.8268 mL	7.0669 mL
	15 mM	0.1885 mL	0.9423 mL	1.8845 mL	4.7113 mL
	20 mM	0.1413 mL	0.7067 mL	1.4134 mL	3.5335 mL
	25 mM	0.1131 mL	0.5654 mL	1.1307 mL	2.8268 mL
	30 mM	0.0942 mL	0.4711 mL	0.9423 mL	2.3556 mL
	40 mM	0.0707 mL	0.3533 mL	0.7067 mL	1.7667 mL
	50 mM	0.0565 mL	0.2827 mL	0.5654 mL	1.4134 mL
	60 mM	0.0471 mL	0.2356 mL	0.4711 mL	1.1778 mL
	80 mM	0.0353 mL	0.1767 mL	0.3533 mL	0.8834 mL
	100 mM	0.0283 mL	0.1413 mL	0.2827 mL	0.7067 mL