1. GPCR/G Protein Neuronal Signaling
  2. Adrenergic Receptor
  3. Propranolol-d7

Propranolol-d7 is the deuterium labeled Propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].

For research use only. We do not sell to patients.

Propranolol-d<sub>7</sub> Chemical Structure

Propranolol-d7 Chemical Structure

CAS No. : 98897-23-5

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5 mg USD 400 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Propranolol-d7 is the deuterium labeled Propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

266.39

Formula

C16H14D7NO2

CAS No.
Unlabeled CAS

525-66-6

Appearance

Solid

Color

White to off-white

SMILES

OC(COC1=C2C=CC=CC2=CC=C1)CNC([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (375.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 100 mg/mL (375.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7539 mL 18.7695 mL 37.5389 mL
5 mM 0.7508 mL 3.7539 mL 7.5078 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 3.7539 mL 18.7695 mL 37.5389 mL 93.8474 mL
5 mM 0.7508 mL 3.7539 mL 7.5078 mL 18.7695 mL
10 mM 0.3754 mL 1.8769 mL 3.7539 mL 9.3847 mL
15 mM 0.2503 mL 1.2513 mL 2.5026 mL 6.2565 mL
20 mM 0.1877 mL 0.9385 mL 1.8769 mL 4.6924 mL
25 mM 0.1502 mL 0.7508 mL 1.5016 mL 3.7539 mL
30 mM 0.1251 mL 0.6256 mL 1.2513 mL 3.1282 mL
40 mM 0.0938 mL 0.4692 mL 0.9385 mL 2.3462 mL
50 mM 0.0751 mL 0.3754 mL 0.7508 mL 1.8769 mL
60 mM 0.0626 mL 0.3128 mL 0.6256 mL 1.5641 mL
80 mM 0.0469 mL 0.2346 mL 0.4692 mL 1.1731 mL
100 mM 0.0375 mL 0.1877 mL 0.3754 mL 0.9385 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Propranolol-d7
Cat. No.:
HY-B0573BS
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