2. Immunology/Inflammation
  3. PSMA
  4. PSMA binder-1

PSMA binder-1 is a ligand for PSMA and can be used to synthesize Ac-PSMA-trillium. Ac-PSMA-trillium is a suitable PSMA-targeting compound with improved PSMA binding properties and pharmacokinetic properties. PSMA ligands have different biological applications after being modified with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or it can be labeled with 225Ac (to obtain Actinium-225-PSMA-Trillium (BAY 3563254)), which has a radioactive killing effect; it can be used as a Macropa chelator for targeted radionuclide therapy (TRT) , has a strong inhibitory effect on metastatic castration-resistant prostate cancer (mCRPC).

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PSMA binder-1 Chemical Structure

PSMA binder-1 Chemical Structure

CAS No. : 2170653-14-0

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Based on 1 publication(s) in Google Scholar

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PSMA binder-1 Related Antibodies

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Description

PSMA binder-1 is a ligand for PSMA and can be used to synthesize Ac-PSMA-trillium. Ac-PSMA-trillium is a suitable PSMA-targeting compound with improved PSMA binding properties and pharmacokinetic properties. PSMA ligands have different biological applications after being modified with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or it can be labeled with 225Ac (to obtain Actinium-225-PSMA-Trillium (BAY 3563254)), which has a radioactive killing effect; it can be used as a Macropa chelator for targeted radionuclide therapy (TRT) , has a strong inhibitory effect on metastatic castration-resistant prostate cancer (mCRPC)[1][2].

Molecular Weight

462.45

Formula

C21H26N4O8
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

C#CC1=CC=CC(NC(NCCCC[C@H](NC(N[C@@H](CCC(O)=O)C(O)=O)=O)C(O)=O)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (64.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1624 mL 10.8120 mL 21.6240 mL
5 mM 0.4325 mL 2.1624 mL 4.3248 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1624 mL 10.8120 mL 21.6240 mL 54.0599 mL
5 mM 0.4325 mL 2.1624 mL 4.3248 mL 10.8120 mL
10 mM 0.2162 mL 1.0812 mL 2.1624 mL 5.4060 mL
15 mM 0.1442 mL 0.7208 mL 1.4416 mL 3.6040 mL
20 mM 0.1081 mL 0.5406 mL 1.0812 mL 2.7030 mL
25 mM 0.0865 mL 0.4325 mL 0.8650 mL 2.1624 mL
30 mM 0.0721 mL 0.3604 mL 0.7208 mL 1.8020 mL
40 mM 0.0541 mL 0.2703 mL 0.5406 mL 1.3515 mL
50 mM 0.0432 mL 0.2162 mL 0.4325 mL 1.0812 mL
60 mM 0.0360 mL 0.1802 mL 0.3604 mL 0.9010 mL
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PSMA binder-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSMA binder-12170653-14-0PSMA binder1PSMA binder 1PSMAProstate-specific membrane antigenPSMA targeting compoundspharmacokinetic propertiesmetastatic castration-resistant prostate cancermCRPCInhibitorinhibitorinhibit

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