2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. PSMA-Val-Cit-PAB-MMAE

PSMA-Val-Cit-PAB-MMAE is a novel small-molecule PSMA-targeted conjugate based on the monomethyl auristatin E for the chemotherapy of prostate cancer.

For research use only. We do not sell to patients.

PSMA-Val-Cit-PAB-MMAE Chemical Structure

PSMA-Val-Cit-PAB-MMAE Chemical Structure

CAS No. : 2748039-79-2

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1 mg USD 1570 In-stock
5 mg USD 3297 In-stock
10 mg USD 5276 In-stock
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Based on 1 publication(s) in Google Scholar

PSMA-Val-Cit-PAB-MMAE Related Antibodies

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Description

PSMA-Val-Cit-PAB-MMAE is a novel small-molecule PSMA-targeted conjugate based on the monomethyl auristatin E for the chemotherapy of prostate cancer.

IC50 & Target

Auristatin

 

Molecular Weight

2267.10

Formula

C114H165ClN20O26
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

OC(CC[C@@H](C(O)=O)NC(N[C@@H](CCCCN(CC1=CC(Cl)=CC=C1)C(CCCCCNC(CCC(N[C@H](C(N[C@H](C(NCCCN2N=NC(CCCC(N[C@H](C(N[C@H](C(NC3=CC=C(C=C3)COC(N([C@H](C(N[C@@H](C(C)C)C(N([C@H]([C@@H](CC(N4CCC[C@]4([C@@H]([C@@H](C)C(N[C@@H]([C@H](C5=CC=CC=C5)O)C)=O)OC)[H])=O)OC)[C@@H](C)CC)C)=O)=O)C(C)C)C)=O)=O)CCCNC(N)=O)=O)C(C)C)=O)=C2)=O)CC6=CC=C(C=C6)O)=O)CC7=CC=CC=C7)=O)=O)=O)C(O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (44.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4411 mL 2.2055 mL 4.4109 mL
5 mM 0.0882 mL 0.4411 mL 0.8822 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4411 mL 2.2055 mL 4.4109 mL 11.0273 mL
5 mM 0.0882 mL 0.4411 mL 0.8822 mL 2.2055 mL
10 mM 0.0441 mL 0.2205 mL 0.4411 mL 1.1027 mL
15 mM 0.0294 mL 0.1470 mL 0.2941 mL 0.7352 mL
20 mM 0.0221 mL 0.1103 mL 0.2205 mL 0.5514 mL
25 mM 0.0176 mL 0.0882 mL 0.1764 mL 0.4411 mL
30 mM 0.0147 mL 0.0735 mL 0.1470 mL 0.3676 mL
40 mM 0.0110 mL 0.0551 mL 0.1103 mL 0.2757 mL
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PSMA-Val-Cit-PAB-MMAE Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSMA-Val-Cit-PAB-MMAE2748039-79-2Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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