(R)-MK-5046

Cat. No.: HY-14342A Purity: 98.21%: FAQs
Data Sheet SDS COA Handling Instructions

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(R)-MK-5046 is the isomer of MK-5046 (HY-14342), and can be used as an experimental control. MK-5046 is a potent, selective and orally active Bombesin receptor subtype-3 (BRS-3) allosteric agonist with an IC₅₀ and an EC₅₀ value of 27 and 25 nM for hBRS-3, respectively. MK-5046 inhibits food intake and reduces body weight of diet-induced obese (DIO) mouse models. MK-5046 can be used for the research of obesity.

For research use only. We do not sell to patients.

(R)-MK-5046 Chemical Structure

CAS No. : 1021736-25-3

Size	Price	Stock	Quantity
1 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 440	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 660	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 990	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of (R)-MK-5046:

MK-5046 In-stock

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Description

Molecular Weight

444.37

Formula

C₂₀H₁₈F₆N₄O

CAS No.

1021736-25-3

Unlabeled CAS

Appearance

Solid

Color

Light yellow to yellow

SMILES

O[C@@](CC1=NC(CC2(C(F)(F)F)CC2)=CN1)(C(F)(F)F)C3=CC=C(N4C=CC=N4)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (450.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2504 mL	11.2519 mL	22.5038 mL
5 mM	0.4501 mL	2.2504 mL	4.5008 mL
10 mM	0.2250 mL	1.1252 mL	2.2504 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.21%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (253 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Guan XM, et al. Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist. J Pharmacol Exp Ther. 2011 Feb;336(2):356-364. [Content Brief]

[2]. Sebhat IK, et al. Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity. ACS Med Chem Lett. 2010 Oct 18;2(1):43-47. [Content Brief]

[3]. Ramos-Alvarez I, et al. The Nonpeptide Agonist MK-5046 Functions As an Allosteric Agonist for the Bombesin Receptor Subtype-3. J Pharmacol Exp Ther. 2022 Aug;382(2):66-78. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2504 mL	11.2519 mL	22.5038 mL	56.2594 mL
	5 mM	0.4501 mL	2.2504 mL	4.5008 mL	11.2519 mL
	10 mM	0.2250 mL	1.1252 mL	2.2504 mL	5.6259 mL
	15 mM	0.1500 mL	0.7501 mL	1.5003 mL	3.7506 mL
	20 mM	0.1125 mL	0.5626 mL	1.1252 mL	2.8130 mL
	25 mM	0.0900 mL	0.4501 mL	0.9002 mL	2.2504 mL
	30 mM	0.0750 mL	0.3751 mL	0.7501 mL	1.8753 mL
	40 mM	0.0563 mL	0.2813 mL	0.5626 mL	1.4065 mL
	50 mM	0.0450 mL	0.2250 mL	0.4501 mL	1.1252 mL
	60 mM	0.0375 mL	0.1875 mL	0.3751 mL	0.9377 mL
	80 mM	0.0281 mL	0.1406 mL	0.2813 mL	0.7032 mL
	100 mM	0.0225 mL	0.1125 mL	0.2250 mL	0.5626 mL

(R)-MK-5046 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-MK-50461021736-25-3Othersselectiveoralallosteric agonistDIObody weightfood intakeobesityInhibitorinhibitorinhibit

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(R)-MK-5046

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Complete Stock Solution Preparation Table

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