2. Membrane Transporter/Ion Channel Neuronal Signaling Autophagy
  3. Calcium Channel Sodium Channel Autophagy
  4. Ranolazine-d8 dihydrochloride

Ranolazine-d8 dihydrochloride  (Synonyms: CVT 303-dd8 dihydrochloride; RS 43285-d8)

Cat. No.: HY-17401S Purity: ≥99.0%
COA Handling Instructions

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Ranolazine-d8 (dihydrochloride) is the deuterium labeled Ranolazine dihydrochloride. Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor[3].

For research use only. We do not sell to patients.

Ranolazine-d<sub>8</sub> dihydrochloride Chemical Structure

Ranolazine-d8 dihydrochloride Chemical Structure

CAS No. : 1219802-60-4

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Based on 1 publication(s) in Google Scholar

Other Forms of Ranolazine-d8 dihydrochloride:

Ranolazine-d8 dihydrochloride Related Antibodies

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Description

Ranolazine-d8 (dihydrochloride) is the deuterium labeled Ranolazine dihydrochloride. Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor[3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ranolazine-d8 dihydrochloride Related Antibodies
Molecular Weight

508.51

Formula

C24H27D8Cl2N3O4
CAS No.
Unlabeled CAS

95635-56-6
Appearance

Solid

Color

White to off-white

SMILES

CC(C=CC=C1C)=C1NC(CN(C([2H])([2H])C2([2H])[2H])C([2H])([2H])C([2H])([2H])N2CC(O)COC3=C(C=CC=C3)OC)=O.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (98.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 50 mg/mL (98.33 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9665 mL 9.8326 mL 19.6653 mL
5 mM 0.3933 mL 1.9665 mL 3.9331 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.9665 mL 9.8326 mL 19.6653 mL 49.1632 mL
5 mM 0.3933 mL 1.9665 mL 3.9331 mL 9.8326 mL
10 mM 0.1967 mL 0.9833 mL 1.9665 mL 4.9163 mL
15 mM 0.1311 mL 0.6555 mL 1.3110 mL 3.2775 mL
20 mM 0.0983 mL 0.4916 mL 0.9833 mL 2.4582 mL
25 mM 0.0787 mL 0.3933 mL 0.7866 mL 1.9665 mL
30 mM 0.0656 mL 0.3278 mL 0.6555 mL 1.6388 mL
40 mM 0.0492 mL 0.2458 mL 0.4916 mL 1.2291 mL
50 mM 0.0393 mL 0.1967 mL 0.3933 mL 0.9833 mL
60 mM 0.0328 mL 0.1639 mL 0.3278 mL 0.8194 mL
80 mM 0.0246 mL 0.1229 mL 0.2458 mL 0.6145 mL
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Ranolazine-d8 dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ranolazine-d81219802-60-4CVT 303-dd8RS 43285-d8Calcium ChannelSodium ChannelAutophagyCa2+ channelsCa channelsNa channelsNa+ channelsInhibitorinhibitorinhibit

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