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  2. CAR-T Related Proteins
  3. TROP-2
  4. TROP-2 Protein, Mouse (246a.a, HEK293, His)

TROP-2 Protein, Mouse (246a.a, HEK293, His)

Cat. No.: HY-P71387
COA Handling Instructions

The TROP-2 protein functions as a growth factor receptor and has been shown to play a critical role in mediating cellular responses associated with growth regulation. Its involvement indicates that it plays a crucial role in signal transduction during cell growth. TROP-2 Protein, Mouse (246a.a, HEK293, His) is the recombinant mouse-derived TROP-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TROP-2 Protein, Mouse (246a.a, HEK293, His) is 246 a.a., with molecular weight of 38-55 kDa.

For research use only. We do not sell to patients.

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  • Biological Activity

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Description

The TROP-2 protein functions as a growth factor receptor and has been shown to play a critical role in mediating cellular responses associated with growth regulation. Its involvement indicates that it plays a crucial role in signal transduction during cell growth. TROP-2 Protein, Mouse (246a.a, HEK293, His) is the recombinant mouse-derived TROP-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TROP-2 Protein, Mouse (246a.a, HEK293, His) is 246 a.a., with molecular weight of 38-55 kDa.

Background

The TROP-2 protein appears to function as a growth factor receptor, suggesting a key role in mediating cellular responses associated with growth regulation. Its involvement in this capacity indicates that TROP-2 may play a crucial role in transducing signals that contribute to cellular growth processes. Further exploration of the specific signaling pathways and downstream effects mediated by TROP-2 as a growth factor receptor could provide valuable insights into its functional significance and potential implications in cellular development and homeostasis.

Species

Mouse

Source

HEK293

Tag

C-6*His

Accession

Q8BGV3 (Q25-G270)

Gene ID

56753  [NCBI]

Molecular Construction
N-term
TROP-2 (Q25-G270)
Accession # Q8BGV3
6*His
C-term
Synonyms
Tumor-associated calcium signal transducer 2; Tacstd2; Trop2; Cell surface glycoprotein Trop-2
AA Sequence

QSNCTCPTNKMTVCDTNGPGGVCQCRAMGSQVLVDCSTLTSKCLLLKARMSARKSGRSLVMPSEHAILDNDGLYDPECDDKGRFKARQCNQTSVCWCVNSVGVRRTDKGDQSLRCDEVVRTHHILIELRHRPTDRAFNHSDLDSELRRLFQERYKLHPSFLSAVHYEEPTIQIELRQNASQKGLRDVDIADAAYYFERDIKGESLFMGRRGLDVQVRGEPLHVERTLIYYLDEKPPQFSMKRLTAG

Molecular Weight

38-55 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US;may vary elsewhere.

Documentation

TROP-2 Protein, Mouse (246a.a, HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
TROP-2 Protein, Mouse (246a.a, HEK293, His)
Cat. No.:
HY-P71387
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