2. Protein Tyrosine Kinase/RTK
  3. RET
  4. RET-IN-21

RET-IN-21 is an inhibitor of receptor tyrosine kinase (RET), with the IC50 of 4.4 μM, that has antitumor activity.

For research use only. We do not sell to patients.

RET-IN-21 Chemical Structure

RET-IN-21 Chemical Structure

CAS No. : 2414373-42-3

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5 mg USD 150 In-stock
10 mg USD 230 In-stock
25 mg USD 390 In-stock
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RET-IN-21 Related Antibodies

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Description

RET-IN-21 is an inhibitor of receptor tyrosine kinase (RET), with the IC50 of 4.4 μM, that has antitumor activity[1].

Molecular Weight

344.37

Formula

C19H16N6O
CAS No.
Unlabeled CAS

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N)C1=CC=C(C2=C3N=C(NCC4=CC=NC=C4)C=CN3N=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (362.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9039 mL 14.5193 mL 29.0385 mL
5 mM 0.5808 mL 2.9039 mL 5.8077 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9039 mL 14.5193 mL 29.0385 mL 72.5963 mL
5 mM 0.5808 mL 2.9039 mL 5.8077 mL 14.5193 mL
10 mM 0.2904 mL 1.4519 mL 2.9039 mL 7.2596 mL
15 mM 0.1936 mL 0.9680 mL 1.9359 mL 4.8398 mL
20 mM 0.1452 mL 0.7260 mL 1.4519 mL 3.6298 mL
25 mM 0.1162 mL 0.5808 mL 1.1615 mL 2.9039 mL
30 mM 0.0968 mL 0.4840 mL 0.9680 mL 2.4199 mL
40 mM 0.0726 mL 0.3630 mL 0.7260 mL 1.8149 mL
50 mM 0.0581 mL 0.2904 mL 0.5808 mL 1.4519 mL
60 mM 0.0484 mL 0.2420 mL 0.4840 mL 1.2099 mL
80 mM 0.0363 mL 0.1815 mL 0.3630 mL 0.9075 mL
100 mM 0.0290 mL 0.1452 mL 0.2904 mL 0.7260 mL
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RET-IN-21 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RET-IN-212414373-42-3RETRET InhibitorCancerInhibitorinhibitorinhibit

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