2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Anti-infection
  3. P-glycoprotein Cytochrome P450 Bacterial Endogenous Metabolite
  4. Roquefortine C

Roquefortine C, a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits P450-3A and other haemoproteins. Roquefortine C has bacteriostatic activities against Gram-positive bacteria.

For research use only. We do not sell to patients.

Roquefortine C Chemical Structure

Roquefortine C Chemical Structure

CAS No. : 58735-64-1

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Roquefortine C Related Antibodies

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Description

Roquefortine C, a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits P450-3A and other haemoproteins. Roquefortine C has bacteriostatic activities against Gram-positive bacteria[1].

Molecular Weight

389.45

Formula

C22H23N5O2
CAS No.
SMILES

O=C([C@](N1C/2=O)([H])C[C@]3(C(C)(C)C=C)[C@@]1([H])NC4=C3C=CC=C4)NC2=C\C5=CN=CN5
Structure Classification
Initial Source

Penicillium roqueforti
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (25.68 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5677 mL 12.8386 mL 25.6772 mL
5 mM 0.5135 mL 2.5677 mL 5.1354 mL
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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5677 mL 12.8386 mL 25.6772 mL 64.1931 mL
5 mM 0.5135 mL 2.5677 mL 5.1354 mL 12.8386 mL
10 mM 0.2568 mL 1.2839 mL 2.5677 mL 6.4193 mL
15 mM 0.1712 mL 0.8559 mL 1.7118 mL 4.2795 mL
20 mM 0.1284 mL 0.6419 mL 1.2839 mL 3.2097 mL
25 mM 0.1027 mL 0.5135 mL 1.0271 mL 2.5677 mL
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Roquefortine C Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Roquefortine C58735-64-1P-glycoproteinCytochrome P450BacterialEndogenous MetaboliteP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243CYPsFungalcyclopeptidePenicilliumroquefortiiP450-3AhaemoproteinsbacteriostaticGram-positivebacteriaInhibitorinhibitorinhibit

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