2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. (RS)-AMPA

(RS)-AMPA  (Synonyms: (±)-AMPA)

Cat. No.: HY-100815B Purity: ≥95.0%
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(RS)-AMPA ((±)-AMPA) is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA does not interfere with binding sites for kainic acid or NMDA receptors.

For research use only. We do not sell to patients.

(RS)-AMPA Chemical Structure

(RS)-AMPA Chemical Structure

CAS No. : 77521-29-0

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5 mg USD 180 In-stock
10 mg USD 290 In-stock
25 mg USD 640 In-stock
50 mg USD 1140 In-stock
100 mg USD 2000 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (RS)-AMPA:

(RS)-AMPA Related Antibodies

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Description

(RS)-AMPA ((±)-AMPA) is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA does not interfere with binding sites for kainic acid or NMDA receptors[1][2].

In Vitro

(RS)-AMPA (10-3-10-4 M) causes depolarizations of cultured rat spinal and brainstem neurones. The depolarization by (RS)-AMPA is clearly dose-dependent, although there is a great variability of effects between individual neurones. Application of (RS)-AMPA at 10-5 M produces only small depolarizations (3-7 mV), whereas at 10-4 M, the amplitudes of the depolarizations ranged from 4 to 33 mV. (RS)-AMPA also causes an increase of the discharge rate of spontaneously firing neurones or sometimes evoked a short burst of action potentials in silent cells. (RS)-AMPA exerts its depolarizing effects by activating glutamate/quisqualate receptors without affecting NMDA receptors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(RS)-AMPA Related Antibodies
Molecular Weight

186.17

Formula

C7H10N2O4
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

O=C1C(CC(N)C(O)=O)=C(C)ON1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (537.14 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3714 mL 26.8572 mL 53.7143 mL
5 mM 1.0743 mL 5.3714 mL 10.7429 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.3714 mL 26.8572 mL 53.7143 mL 134.2859 mL
5 mM 1.0743 mL 5.3714 mL 10.7429 mL 26.8572 mL
10 mM 0.5371 mL 2.6857 mL 5.3714 mL 13.4286 mL
15 mM 0.3581 mL 1.7905 mL 3.5810 mL 8.9524 mL
20 mM 0.2686 mL 1.3429 mL 2.6857 mL 6.7143 mL
25 mM 0.2149 mL 1.0743 mL 2.1486 mL 5.3714 mL
30 mM 0.1790 mL 0.8952 mL 1.7905 mL 4.4762 mL
40 mM 0.1343 mL 0.6714 mL 1.3429 mL 3.3571 mL
50 mM 0.1074 mL 0.5371 mL 1.0743 mL 2.6857 mL
60 mM 0.0895 mL 0.4476 mL 0.8952 mL 2.2381 mL
80 mM 0.0671 mL 0.3357 mL 0.6714 mL 1.6786 mL
100 mM 0.0537 mL 0.2686 mL 0.5371 mL 1.3429 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(RS)-AMPA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(RS)-AMPA77521-29-0(±)-AMPAiGluRIonotropic glutamate receptorsDepolarizationsmotoneuronesinterneuronesglutamateCNSkainicL-glutamicneurotransmitterNMDAInhibitorinhibitorinhibit

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