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BRK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	BRK (4) Small Interfering RNA (siRNA) (1) Tie (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1)

5

Inhibitors & Agonists

3

Recombinant Proteins

1

Antibodies

Targets Recommended: BRK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

SB-633825 2 Publications Verification	Tie BRK	Cardiovascular Disease Cancer
SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and *BRK* with IC₅₀s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis .

Tilfrinib	BRK	Cancer
Tilfrinib (compound 4f) is a potent and selective *Brk/PTK6* inhibitor with an IC₅₀ value of 3.15 nM for *Brk*. Tilfrinib shows good anti-proliferative activity and has potential of anti-tumour .

BRK inhibitor P21d hydrochloride	BRK	Cancer
BRK inhibitor P21d hydrochloride is a potent breast tumor kinase (BRK/PTK6) inhibitor with an IC₅₀ of 30 nM. BRK inhibitor P21d hydrochloride inhibits p-SAM68 with an IC₅₀ of 52 nM. BRK inhibitor P21d hydrochloride can be used to evaluate the in vivo activity of BRK inhibitors in xenograft breast tumor models .

BRK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BRK1 Human Pre-designed siRNA Set A contains three designed siRNAs for BRK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BRK1 Human Pre-designed siRNA Set A BRK1 Human Pre-designed siRNA Set A

XMU-MP-2	BRK	Cancer
XMU-MP-2 is a *BRK* inhibitor with significant inhibitory activity on BRK-positive cells. XMU-MP-2 inhibits oncogenic BRK-driven tumor growth in a mouse xenograft model. XMU-MP-2 also synergizes with HER2 inhibitors or endoplasmic reticulum (ER) blockade to exert antiproliferative activity .

Species:	Human (2) Mouse (1)
Tag:	His (2) GST (3)
Source:	Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source

	Brk Protein, Human (sf9, GST) Protein-tyrosine kinase 6; SRC-related intestinal kinase; Ptk6; Sik	Human	Sf9 insect cells
	Brk is a nonreceptor tyrosine protein kinase that regulates signaling pathways critical for epithelial tissue differentiation, normal maintenance, and tumor growth. Context-dependent functions involve a variety of substrates, including RNA-binding proteins, transcription factors, and signaling molecules. Brk Protein, Human (sf9, GST) is the recombinant human-derived Brk protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of Brk Protein, Human (sf9, GST) is 451 a.a., with molecular weight of ~70 kDa.

	Brk Protein, Mouse (sf9, His-GST) Protein-tyrosine kinase 6; SRC-related intestinal kinase; Ptk6; Sik	Mouse	Sf9 insect cells
	Brk protein is a non-receptor tyrosine protein kinase that regulates signaling pathways critical for epithelial differentiation and tumor growth. Its context-dependent functions involve phosphorylating substrates such as RNA-binding proteins, transcription factors, and signaling molecules. Brk Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived Brk protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of Brk Protein, Mouse (sf9, His-GST) is 451 a.a., with molecular weight of ~66 kDa.

	Brk/PTK6 Protein, Human (sf9, His, GST) PTK6; PTK6 protein tyrosine kinase 6; protein-tyrosine kinase 6; BRK; breast tumor kinase; protein-tyrosine kinase BRK; tyrosine-protein kinase BRK; FLJ42088	Human	Sf9 insect cells

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