2. GPCR/G Protein
  3. Secretin Receptor
  4. Secretin (swine)

Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Secretin (swine) Chemical Structure

Secretin (swine) Chemical Structure

CAS No. : 17034-35-4

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5 mg USD 225 In-stock
10 mg USD 360 In-stock
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Based on 1 publication(s) in Google Scholar

Secretin (swine) Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism[1][2].

In Vitro

Secretin (swine) (10−7M, 10−6M; 24 to 72 h and 7 days) stimulates biliary growth by interaction with secretin receptors (SR) and knockout of SR reduces biliary proliferation by downregulating cAMP dependent signaling[2].
Secretin (10−7M, 10−6M; 24 to 72 h and 7 days) increases the proliferation in human HIBEpiC and large murine cholangiocyte lines[2][3][4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Secretin (swine) Related Antibodies
In Vivo

Secretin (swine) (2.5 nM/kg, BW/day, osmotic minipumps, for 1 week) stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sct＋/－mice[2]
Dosage: 2.5 nM/kg
Administration: 2.5 nM/kg, BW/day, osmotic minipumps, for 1 week
Result: Increased in supernatants from cholangiocytes and S cells and in serum and bile following BDL in control mice.
Had low IBDM, reduced proliferation, and reduced production of vascular endothelial growth factor A (VEGFA) and nerve growth factor (NGF) in BDL Sct＋/－mice.
Regulated VEGF and NGF expression that negatively correlated with microRNA 125b and let7a levels in liver tissue[2].
Molecular Weight

3055.41

Formula

C130H220N44O41
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

Sequence

His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2
Sequence Shortening

HSDGTFTSELSRLRDSARLQRLLQGLV-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 66.67 mg/mL (21.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3273 mL 1.6364 mL 3.2729 mL
5 mM 0.0655 mL 0.3273 mL 0.6546 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.3273 mL 1.6364 mL 3.2729 mL 8.1822 mL
5 mM 0.0655 mL 0.3273 mL 0.6546 mL 1.6364 mL
10 mM 0.0327 mL 0.1636 mL 0.3273 mL 0.8182 mL
15 mM 0.0218 mL 0.1091 mL 0.2182 mL 0.5455 mL
20 mM 0.0164 mL 0.0818 mL 0.1636 mL 0.4091 mL
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Secretin (swine) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Secretin (swine)17034-35-4Secretin ReceptorSCTRneuroendocrine hormoneS cellspeptidesecretin receptorsenteroendocrine celldigestive systemcentral nervous systemenergy metabolismInhibitorinhibitorinhibit

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Secretin (swine)
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