SiR-COOH

Cat. No.: HY-D1345: FAQs
Data Sheet Handling Instructions

Molarity Calculator

SiR-COOH could be used to follow the intracellular location of the model therapeutic agent in GFP cells (Abs, 645 nm; Em, 676 nm).

For research use only. We do not sell to patients.

SiR-COOH Chemical Structure

CAS No. : 1418275-26-9

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description	SiR-COOH could be used to follow the intracellular location of the model therapeutic agent in GFP cells (Abs, 645 nm; Em, 676 nm)^[1].
In Vitro	SiR-COOH could be used to conjugated inhibitors such as UNC2025 (Mer inhibitor). SiR-COOH is especially useful for small-molecule probes: it exhibits bright photostable fluorescence at near-infrared wavelengths, which are ideal for imaging deep through tissue; fluorescence is robust across physiological environments with little toxicity; it is amenable to super-resolution microscopy; and it exhibits an optimal degree of hydrophilicity for live-cell imaging^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. SiR-COOH Related Antibodies
Molecular Weight	472.61
Formula	C₂₇H₂₈N₂O₄Si
CAS No.	1418275-26-9
Unlabeled CAS
Emission (Em)	674
Excitation (Ex)	652
SMILES	O=C(C1=C(C(C2=C([Si](C)(C)C3=C/4)C=C(N(C)C)C=C2)=C3C=CC4=[N+](C)\C)C=C(C(O)=O)C=C1)[O-]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (273 KB) Handling Instructions (2659 KB)
References	[1]. Eunha Kim, et al. Red Si-rhodamine drug conjugates enable imaging in GFP cells. Chem Commun (Camb). 2014 May 4;50(34):4504-7. [Content Brief] [2]. Miles A Miller, et al. Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease. Chem Commun (Camb). 2017 Dec 19;54(1):42-45.https://pubmed.ncbi.nlm.nih.gov/29185561 [Content Brief]

SiR-COOH Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SiR-COOH1418275-26-9Fluorescent DyeGFPProbelittletoxicityInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name			Lot #
Applicant Name *			Email Address *
Phone Number			Department *
Organization Name *			Country or Region *
Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

SiR-COOH

SiR-COOH Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review